Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 8/20 | 0.51 |
| ▸ | MAP3K12 | Q12852 | 4/20 | 0.46 |
| ▸ | KARS1 | Q15046 | 7/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13136323 | 0.92 | SYK (0.53) | SYKMAP3K12KARS1KDR | |
| SCHEMBL2862462 | 0.92 | SYK (0.49) | SYKKARS1 | |
| SCHEMBL13136308 | 0.90 | SYK (0.48) | SYKMAP3K12KARS1 | |
| SCHEMBL2876774 | 0.90 | SYK (0.48) | SYKMAP3K12KARS1 | |
| SCHEMBL13136304 | 0.90 | SYK (0.48) | SYKKARS1 | |
| SCHEMBL14390970 | 0.90 | SYK (0.49) | SYKMAP3K12KARS1 | |
| SCHEMBL13136303 | 0.89 | SYK (0.47) | SYKMAP3K12KARS1 | |
| SCHEMBL2866251 | 0.87 | SYK (0.47) | SYKKARS1KDR | |
| SCHEMBL2862308 | 0.86 | SYK (0.56) | SYKKARS1 | |
| SCHEMBL2870064 | 0.86 | SYK (0.51) | SYKKARS1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7803801-B2 | Aminopyridine compounds having Syk inhibitory activity | JAPAN TOBACCO, INC. (JP) | 2010-09-28 | — | — | US | disclosed |
| US-7803801-B2 | Aminopyridine compounds having Syk inhibitory activity | JAPAN TOBACCO, INC. (JP) | 2010-09-28 | — | — | US | disclosed |