SCHEMBL13136304

SCHEMBL13136304

Cc1ccnc(Nc2cccc(-c3cnc(CCC4CCN(C(=O)C5CCC(O)CC5)CC4)s3)n2)c1

nearest known ligand 0.48

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
SYK P43405 12/20 0.48
KARS1 Q15046 8/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2876774 0.92 SYK (0.48) SYKKARS1
SCHEMBL13136303 0.92 SYK (0.47) SYKKARS1
SCHEMBL13136274 0.90 SYK (0.51) SYKKARS1
SCHEMBL2870064 0.90 SYK (0.51) SYKKARS1
SCHEMBL13136282 0.89 SYK (0.49) SYKKARS1
SCHEMBL2862462 0.88 SYK (0.49) SYKKARS1
SCHEMBL13136308 0.87 SYK (0.48) SYKKARS1
SCHEMBL13136405 0.86 SYK (0.51) SYKKARS1
SCHEMBL2862308 0.86 SYK (0.56) SYKKARS1
SCHEMBL14390970 0.86 SYK (0.49) SYKKARS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7803801-B2 Aminopyridine compounds having Syk inhibitory activity JAPAN TOBACCO, INC. (JP) 2010-09-28 US disclosed
US-7803801-B2 Aminopyridine compounds having Syk inhibitory activity JAPAN TOBACCO, INC. (JP) 2010-09-28 US disclosed