Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 6/20 | 0.51 |
| ▸ | KARS1 | Q15046 | 8/20 | 0.46 |
| ▸ | IKBKB | O14920 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13136289 | 0.86 | SYK (0.47) | SYKKARS1MAP3K12 | |
| SCHEMBL13136197 | 0.84 | SYK (0.53) | SYKKARS1KDRJAK2 | |
| SCHEMBL13136238 | 0.84 | KARS1 (0.47) | SYKKARS1KDR | |
| SCHEMBL13136200 | 0.83 | SYK (0.53) | SYKKARS1KDRJAK2 | |
| SCHEMBL13136270 | 0.83 | SYK (0.55) | SYKKARS1KDRJAK2 | |
| SCHEMBL13136299 | 0.82 | SYK (0.51) | SYKKARS1KDR | |
| SCHEMBL13136179 | 0.82 | SYK (0.53) | SYKKARS1KDRMEN1RAB9A | |
| SCHEMBL2869899 | 0.82 | SYK (0.48) | SYKKARS1IKBKBKDRMAP3K12 | |
| SCHEMBL2864865 | 0.82 | SYK (0.48) | SYKKARS1IKBKBKDRMAP3K12 | |
| SCHEMBL13136245 | 0.81 | SYK (0.53) | SYKKARS1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7803801-B2 | Aminopyridine compounds having Syk inhibitory activity | JAPAN TOBACCO, INC. (JP) | 2010-09-28 | — | — | US | disclosed |
| US-7803801-B2 | Aminopyridine compounds having Syk inhibitory activity | JAPAN TOBACCO, INC. (JP) | 2010-09-28 | — | — | US | disclosed |