Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 4/20 | 0.51 |
| ▸ | KARS1 | Q15046 | 6/20 | 0.48 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | KCNN1 | Q92952 | 1/20 | 0.44 |
| ▸ | KCNN2 | Q9H2S1 | 1/20 | 0.44 |
| ▸ | KCNN3 | Q9UGI6 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13136333 | 0.93 | SYK (0.47) | SYKKARS1KDRKCNN1KCNN2 | |
| SCHEMBL2859100 | 0.89 | KARS1 (0.52) | SYKKARS1KDRKCNN1KCNN2 | |
| SCHEMBL13136024 | 0.88 | KARS1 (0.51) | SYKKARS1KDRKCNN1KCNN2 | |
| SCHEMBL13136159 | 0.87 | SYK (0.51) | SYKKARS1KDRKCNN1KCNN2 | |
| SCHEMBL13136054 | 0.87 | KARS1 (0.50) | SYKKARS1KDRKCNN1KCNN2 | |
| SCHEMBL13136025 | 0.87 | KARS1 (0.50) | SYKKARS1KDRKCNN1KCNN2 | |
| SCHEMBL2872543 | 0.86 | KARS1 (0.50) | SYKKARS1KDRKCNN1KCNN2 | |
| SCHEMBL13136053 | 0.86 | SYK (0.49) | SYKKARS1KDRKCNN1KCNN2 | |
| SCHEMBL13136177 | 0.84 | SYK (0.54) | SYKKARS1 | |
| SCHEMBL13135987 | 0.84 | SYK (0.47) | SYKKARS1KDRKCNN1KCNN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7803801-B2 | Aminopyridine compounds having Syk inhibitory activity | JAPAN TOBACCO, INC. (JP) | 2010-09-28 | — | — | US | disclosed |
| US-7803801-B2 | Aminopyridine compounds having Syk inhibitory activity | JAPAN TOBACCO, INC. (JP) | 2010-09-28 | — | — | US | disclosed |