Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 3/20 | 0.48 |
| ▸ | KARS1 | Q15046 | 8/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13136384 | 0.85 | SYK (0.48) | SYKKARS1KDR | |
| SCHEMBL13136179 | 0.85 | SYK (0.53) | SYKKARS1MAPTNPC1RAB9A | |
| SCHEMBL13136220 | 0.84 | SYK (0.51) | SYKKARS1KDR | |
| SCHEMBL13136270 | 0.84 | SYK (0.55) | SYKKARS1KDR | |
| SCHEMBL13136269 | 0.84 | KARS1 (0.54) | SYKKARS1KDR | |
| SCHEMBL13136229 | 0.84 | SYK (0.52) | SYKKARS1KDR | |
| SCHEMBL13136197 | 0.83 | SYK (0.53) | SYKKARS1KDR | |
| SCHEMBL13136240 | 0.80 | KARS1 (0.58) | SYKKARS1NPC1RAB9AKDR | |
| SCHEMBL2865935 | 0.79 | KARS1 (0.56) | SYKKARS1NPC1RAB9AKDR | |
| SCHEMBL13136268 | 0.79 | SYK (0.50) | SYKKARS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7803801-B2 | Aminopyridine compounds having Syk inhibitory activity | JAPAN TOBACCO, INC. (JP) | 2010-09-28 | — | — | US | disclosed |
| US-7803801-B2 | Aminopyridine compounds having Syk inhibitory activity | JAPAN TOBACCO, INC. (JP) | 2010-09-28 | — | — | US | disclosed |