Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 7/20 | 0.50 |
| ▸ | KARS1 | Q15046 | 7/20 | 0.49 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.42 |
| ▸ | MAP3K12 | Q12852 | 3/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13136397 | 0.93 | SYK (0.50) | SYKKARS1MAP3K12 | |
| SCHEMBL2861431 | 0.92 | KARS1 (0.55) | SYKKARS1EGFR | |
| SCHEMBL13136418 | 0.91 | SYK (0.49) | SYKKARS1MAP3K12 | |
| SCHEMBL2859023 | 0.89 | SYK (0.57) | SYKKARS1 | |
| SCHEMBL2866148 | 0.88 | SYK (0.53) | SYKKARS1EGFR | |
| SCHEMBL13136406 | 0.87 | SYK (0.52) | SYKKARS1 | |
| SCHEMBL2863557 | 0.87 | SYK (0.52) | SYKKARS1PRKD1 | |
| SCHEMBL2863920 | 0.87 | KARS1 (0.52) | SYKKARS1MAP3K12 | |
| SCHEMBL2863927 | 0.87 | KARS1 (0.52) | SYKKARS1MAP3K12 | |
| SCHEMBL2869781 | 0.87 | SYK (0.50) | SYKKARS1MAP3K12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7803801-B2 | Aminopyridine compounds having Syk inhibitory activity | JAPAN TOBACCO, INC. (JP) | 2010-09-28 | — | — | US | disclosed |
| US-7803801-B2 | Aminopyridine compounds having Syk inhibitory activity | JAPAN TOBACCO, INC. (JP) | 2010-09-28 | — | — | US | disclosed |
| EP-1854793-A1 | NOVEL AMINOPYRIDINE COMPOUND WITH Syk INHIBITORY ACTIVITY | Japan Tobacco, Inc. (JP) | 2007-11-14 | — | — | EP | disclosed |