Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 12/20 | 0.53 |
| ▸ | SYK | P43405 | 1/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.41 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13136552 | 0.88 | KARS1 (0.56) | KARS1SYKJAK2MEN1NPC1 | |
| SCHEMBL2864883 | 0.88 | KARS1 (0.56) | KARS1SYKJAK2MEN1NPC1 | |
| SCHEMBL2869562 | 0.87 | KARS1 (0.55) | KARS1SYKJAK2MEN1NPC1 | |
| SCHEMBL2856828 | 0.86 | KARS1 (0.54) | KARS1SYKJAK2MEN1NPC1 | |
| SCHEMBL13136551 | 0.86 | KARS1 (0.54) | KARS1SYKJAK2MEN1NPC1 | |
| SCHEMBL13136575 | 0.85 | KARS1 (0.53) | KARS1SYKJAK2MEN1NPC1 | |
| SCHEMBL13136576 | 0.85 | KARS1 (0.53) | KARS1SYKJAK2MEN1NPC1 | |
| SCHEMBL13177675 | 0.84 | KARS1 (0.54) | KARS1SYKJAK2MEN1NPC1 | |
| SCHEMBL13136665 | 0.84 | KARS1 (0.44) | KARS1SYKJAK2HSD17B1HSD17B2 | |
| SCHEMBL2880104 | 0.83 | KARS1 (0.53) | KARS1SYKJAK2MEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7803801-B2 | Aminopyridine compounds having Syk inhibitory activity | JAPAN TOBACCO, INC. (JP) | 2010-09-28 | — | — | US | disclosed |
| US-7803801-B2 | Aminopyridine compounds having Syk inhibitory activity | JAPAN TOBACCO, INC. (JP) | 2010-09-28 | — | — | US | disclosed |