Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | KARS1 | Q15046 | 11/20 | 0.47 |
| ▸ | SYK | P43405 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.42 |
| ▸ | CDK1 | P06493 | 1/20 | 0.42 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | CDK7 | P50613 | 1/20 | 0.42 |
| ▸ | CDK9 | P50750 | 1/20 | 0.42 |
| ▸ | CCNH | P51946 | 1/20 | 0.42 |
| ▸ | MAP3K12 | Q12852 | 2/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13136608 | 0.90 | KARS1 (0.47) | KARS1SYKMAP3K12 | |
| SCHEMBL2868322 | 0.89 | KARS1 (0.56) | KARS1SYKMAP3K12 | |
| SCHEMBL13136599 | 0.88 | KARS1 (0.49) | KARS1SYKMAP3K12 | |
| SCHEMBL13136661 | 0.86 | SYK (0.51) | KARS1SYKMAP3K12 | |
| SCHEMBL13136658 | 0.84 | SYK (0.48) | KARS1SYKMAP3K12 | |
| SCHEMBL2864883 | 0.82 | KARS1 (0.56) | RAB9ANPC1ALDH1A1MAPTKARS1 | |
| SCHEMBL13136552 | 0.82 | KARS1 (0.56) | RAB9ANPC1KARS1SYKKDM4E | |
| SCHEMBL13177725 | 0.81 | SYK (0.48) | KARS1SYKMAP3K12 | |
| SCHEMBL2869562 | 0.81 | KARS1 (0.55) | RAB9ANPC1ALDH1A1MAPTKARS1 | |
| SCHEMBL13136551 | 0.80 | KARS1 (0.54) | RAB9ANPC1KARS1SYKKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7803801-B2 | Aminopyridine compounds having Syk inhibitory activity | JAPAN TOBACCO, INC. (JP) | 2010-09-28 | — | — | US | disclosed |
| US-7803801-B2 | Aminopyridine compounds having Syk inhibitory activity | JAPAN TOBACCO, INC. (JP) | 2010-09-28 | — | — | US | disclosed |