Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 7/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 5/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13136582 | 0.93 | SYK (0.42) | KARS1CYP3A4CYP2A6CYP2C9CYP2C19 | |
| SCHEMBL13136586 | 0.92 | ROCK1 (0.41) | KARS1CYP3A4CYP2A6CYP2C9CYP2C19 | |
| SCHEMBL2866365 | 0.91 | ROCK1 (0.43) | KARS1CYP3A4CYP2A6CYP2C9CYP2C19 | |
| SCHEMBL2864883 | 0.88 | KARS1 (0.56) | KARS1SYKALDH1A1KDM4ELMNA | |
| SCHEMBL2869691 | 0.87 | SYK (0.51) | KARS1CYP3A4CYP2A6CYP2C9CYP2C19 | |
| SCHEMBL13136589 | 0.85 | HDAC1 (0.50) | CYP3A4CYP2A6CYP2C9CYP2C19HDAC1 | |
| SCHEMBL13136623 | 0.85 | KARS1 (0.41) | KARS1CYP3A4CYP2A6CYP2C9CYP2C19 | |
| SCHEMBL2871454 | 0.85 | KDR (0.47) | KARS1CYP3A4CYP2A6CYP2C9CYP2C19 | |
| SCHEMBL13136579 | 0.84 | KARS1 (0.42) | KARS1CYP3A4CYP2A6CYP2C9CYP2C19 | |
| SCHEMBL13136585 | 0.84 | IDH2 (0.41) | KARS1CYP3A4CYP2A6CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7803801-B2 | Aminopyridine compounds having Syk inhibitory activity | JAPAN TOBACCO, INC. (JP) | 2010-09-28 | — | — | US | disclosed |
| US-7803801-B2 | Aminopyridine compounds having Syk inhibitory activity | JAPAN TOBACCO, INC. (JP) | 2010-09-28 | — | — | US | disclosed |