Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 8/20 | 0.47 |
| ▸ | SYK | P43405 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | AKT3 | Q9Y243 | 6/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13136569 | 0.91 | KARS1 (0.47) | KARS1SYKMEN1NPC1RAB9A | |
| SCHEMBL14390677 | 0.90 | KARS1 (0.49) | KARS1SYKMEN1NPC1RAB9A | |
| SCHEMBL13136555 | 0.87 | KARS1 (0.58) | KARS1SYKMEN1NPC1RAB9A | |
| SCHEMBL13136634 | 0.85 | KARS1 (0.49) | KARS1SYKMEN1NPC1RAB9A | |
| SCHEMBL2871084 | 0.84 | AKT3 (0.58) | KARS1SYKMEN1NPC1RAB9A | |
| SCHEMBL2856828 | 0.83 | KARS1 (0.54) | KARS1SYKMEN1NPC1RAB9A | |
| SCHEMBL13136629 | 0.83 | KARS1 (0.48) | KARS1SYKMEN1NPC1RAB9A | |
| SCHEMBL13136631 | 0.81 | KARS1 (0.47) | KARS1SYKMEN1NPC1RAB9A | |
| SCHEMBL13136595 | 0.81 | KARS1 (0.48) | KARS1SYKMEN1NPC1RAB9A | |
| SCHEMBL13136552 | 0.81 | KARS1 (0.56) | KARS1SYKMEN1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7803801-B2 | Aminopyridine compounds having Syk inhibitory activity | JAPAN TOBACCO, INC. (JP) | 2010-09-28 | — | — | US | disclosed |
| US-7803801-B2 | Aminopyridine compounds having Syk inhibitory activity | JAPAN TOBACCO, INC. (JP) | 2010-09-28 | — | — | US | disclosed |
| EP-1854793-A1 | NOVEL AMINOPYRIDINE COMPOUND WITH Syk INHIBITORY ACTIVITY | Japan Tobacco, Inc. (JP) | 2007-11-14 | — | — | EP | disclosed |