Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 12/20 | 0.48 |
| ▸ | SYK | P43405 | 2/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | S1PR5 | Q9H228 | 3/20 | 0.39 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13136200 | 0.87 | SYK (0.53) | KARS1SYKJAK2KDR | |
| SCHEMBL2863219 | 0.84 | KARS1 (0.46) | KARS1SYKJAK2KDRS1PR5 | |
| SCHEMBL13136629 | 0.83 | KARS1 (0.48) | KARS1SYKJAK2 | |
| SCHEMBL13136556 | 0.82 | KARS1 (0.53) | KARS1SYKKDR | |
| SCHEMBL2859009 | 0.82 | KARS1 (0.45) | KARS1SYKJAK2KDR | |
| SCHEMBL13136662 | 0.82 | SYK (0.50) | KARS1SYK | |
| Hydrochloric Acid SCHEMBL2865736 | 0.81 | KARS1 (0.45) | KARS1SYKJAK2KDR | |
| SCHEMBL2872532 | 0.81 | KARS1 (0.57) | KARS1SYKJAK2KDR | |
| SCHEMBL13136613 | 0.80 | KARS1 (0.55) | KARS1SYKKDR | |
| SCHEMBL2868318 | 0.80 | SYK (0.51) | KARS1SYKJAK2KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7803801-B2 | Aminopyridine compounds having Syk inhibitory activity | JAPAN TOBACCO, INC. (JP) | 2010-09-28 | — | — | US | disclosed |
| US-7803801-B2 | Aminopyridine compounds having Syk inhibitory activity | JAPAN TOBACCO, INC. (JP) | 2010-09-28 | — | — | US | disclosed |