Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.51 |
| ▸ | KARS1 | Q15046 | 11/20 | 0.49 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.43 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2856828 | 0.86 | KARS1 (0.54) | SYKKARS1NPC1RAB9AKDM4E | |
| SCHEMBL13136552 | 0.84 | KARS1 (0.56) | SYKKARS1NPC1RAB9AKDM4E | |
| SCHEMBL2864883 | 0.84 | KARS1 (0.56) | SYKKARS1NPC1RAB9AKDM4E | |
| SCHEMBL13136555 | 0.84 | KARS1 (0.58) | SYKKARS1NPC1RAB9AMEN1 | |
| SCHEMBL13136588 | 0.84 | KARS1 (0.51) | SYKKARS1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2871084 | 0.83 | AKT3 (0.58) | SYKKARS1NPC1RAB9AMEN1 | |
| SCHEMBL2869562 | 0.83 | KARS1 (0.55) | SYKKARS1NPC1RAB9AKDM4E | |
| SCHEMBL13136629 | 0.82 | KARS1 (0.48) | SYKKARS1NPC1RAB9AMEN1 | |
| SCHEMBL13136551 | 0.82 | KARS1 (0.54) | SYKKARS1NPC1RAB9AKDM4E | |
| SCHEMBL13136634 | 0.82 | KARS1 (0.49) | SYKKARS1NPC1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7803801-B2 | Aminopyridine compounds having Syk inhibitory activity | JAPAN TOBACCO, INC. (JP) | 2010-09-28 | — | — | US | disclosed |
| US-7803801-B2 | Aminopyridine compounds having Syk inhibitory activity | JAPAN TOBACCO, INC. (JP) | 2010-09-28 | — | — | US | disclosed |