Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 9/20 | 0.46 |
| ▸ | SYK | P43405 | 4/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2873330 | 0.88 | SYK (0.52) | KARS1SYKNPC1RAB9APKM | |
| SCHEMBL2863219 | 0.84 | KARS1 (0.46) | KARS1SYKSMN1; SMN2JAK2KDR | |
| SCHEMBL13136670 | 0.84 | SYK (0.46) | KARS1SYKJAK2KDR | |
| SCHEMBL2865293 | 0.81 | KARS1 (0.43) | KARS1SYKNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL13136650 | 0.80 | SYK (0.45) | KARS1SYKJAK2KDR | |
| SCHEMBL2862164 | 0.80 | KARS1 (0.42) | KARS1SYKSMN1; SMN2JAK2ALDH1A1 | |
| SCHEMBL2872532 | 0.80 | KARS1 (0.57) | KARS1SYKNPC1RAB9AJAK2 | |
| SCHEMBL2864163 | 0.80 | SYK (0.42) | KARS1SYKSMN1; SMN2JAK2ALDH1A1 | |
| SCHEMBL13136552 | 0.79 | KARS1 (0.56) | KARS1SYKNPC1RAB9AJAK2 | |
| SCHEMBL13136613 | 0.79 | KARS1 (0.55) | KARS1SYKNPC1RAB9AKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7803801-B2 | Aminopyridine compounds having Syk inhibitory activity | JAPAN TOBACCO, INC. (JP) | 2010-09-28 | — | — | US | disclosed |
| US-7803801-B2 | Aminopyridine compounds having Syk inhibitory activity | JAPAN TOBACCO, INC. (JP) | 2010-09-28 | — | — | US | disclosed |