Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 2/20 | 0.71 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.71 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | BACE1 | P56817 | 2/20 | 0.42 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.39 |
| ▸ | PADI4 | Q9UM07 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13139101 | 0.94 | HCRTR1 (0.66) | HCRTR1HCRTR2NPC1RAB9ABACE1 | |
| SCHEMBL13139093 | 0.93 | HCRTR1 (0.77) | HCRTR1HCRTR2NPC1RAB9ABACE1 | |
| SCHEMBL13139060 | 0.91 | HCRTR1 (0.77) | HCRTR1HCRTR2NPC1RAB9AHDAC3 | |
| SCHEMBL2011910 | 0.91 | HCRTR1 (0.69) | HCRTR1HCRTR2NPC1RAB9APOLB | |
| SCHEMBL13139095 | 0.90 | HCRTR1 (0.70) | HCRTR1HCRTR2NPC1RAB9AHDAC3 | |
| SCHEMBL13139077 | 0.88 | HCRTR1 (0.75) | HCRTR1HCRTR2NPC1RAB9AHRH3 | |
| SCHEMBL2013519 | 0.88 | HCRTR1 (0.68) | HCRTR1HCRTR2NPC1RAB9AHDAC3 | |
| SCHEMBL2049210 | 0.88 | HCRTR1 (0.68) | HCRTR1HCRTR2NPC1RAB9AHDAC3 | |
| SCHEMBL2053280 | 0.88 | HCRTR1 (0.68) | HCRTR1HCRTR2NPC1RAB9AHDAC3 | |
| SCHEMBL2012507 | 0.88 | HCRTR1 (0.68) | HCRTR1HCRTR2NPC1RAB9AHDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100222396-A1 | 4-ARYL-BUTANE-1,3-DIAMIDES | NOVARTIS AG (CH) | 2010-09-02 | — | — | US | disclosed |
| US-20100222396-A1 | 4-ARYL-BUTANE-1,3-DIAMIDES | NOVARTIS AG (CH) | 2010-09-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100222396-A1 | 4-ARYL-BUTANE-1,3-DIAMIDES | CYP11B2, CYP11B1, BBC3 | HCRTR1 3230/4885HCRTR2 3029/4885NPC1 686/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.