Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | CA12 | O43570 | 2/20 | 0.42 |
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | CA4 | P22748 | 2/20 | 0.42 |
| ▸ | CA6 | P23280 | 2/20 | 0.42 |
| ▸ | CA7 | P43166 | 2/20 | 0.42 |
| ▸ | CA9 | Q16790 | 2/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CA5A | P35218 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | CA3 | P07451 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14732689 | 0.89 | LMNA (0.55) | LMNAKMT2AMEN1ALDH1A1CYP3A4 | |
| SCHEMBL12303222 | 0.84 | LMNA (0.62) | LMNAKMT2AMEN1ALDH1A1CA12 | |
| SCHEMBL10317061 | 0.82 | MAPT (0.50) | LMNAKMT2AMEN1ALDH1A1CA12 | |
| SCHEMBL28520091 | 0.81 | LMNA (0.58) | LMNAKMT2AMEN1ALDH1A1CA12 | |
| SCHEMBL16450475 | 0.79 | LMNA (0.56) | LMNAKMT2AMEN1ALDH1A1CA12 | |
| SCHEMBL24488761 | 0.79 | LMNA (0.67) | LMNAKMT2AMEN1ALDH1A1CA12 | |
| SCHEMBL10317700 | 0.78 | HSD17B2 (0.59) | LMNAKMT2AMEN1ALDH1A1CA12 | |
| SCHEMBL13970537 | 0.78 | LMNA (0.70) | LMNAKMT2AMEN1ALDH1A1CA12 | |
| Acetosyringone SCHEMBL15511 | 0.77 | LMNA (1.00) | LMNAKMT2AMEN1ALDH1A1CA12 | |
| SCHEMBL12327904 | 0.77 | LMNA (0.69) | LMNAKMT2AMEN1ALDH1A1CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8552066-B2 | Modified chalcone compounds as antimitotic agents | ARIZONA BIOMEDICAL RESEARCH COMMISSION (US) | 2013-10-08 | — | — | US | disclosed |
| US-20100222380-A1 | Modified Chalcone Compounds as Antimitotic Agents | ARIZONA BIOMEDICAL RESEARCH COMMISSION (US) | 2010-09-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100222380-A1 | Modified Chalcone Compounds as Antimitotic Agents | TUBA1C, SARS1, TUBB1 | LMNA 868/4885KMT2A 4469/4885MEN1 4427/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.