Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIKFYVE | Q9Y2I7 | 4/20 | 0.76 |
| ▸ | FES | P07332 | 1/20 | 0.76 |
| ▸ | FER | P16591 | 1/20 | 0.76 |
| ▸ | TYK2 | P29597 | 1/20 | 0.76 |
| ▸ | FRK | P42685 | 1/20 | 0.76 |
| ▸ | SYK | P43405 | 1/20 | 0.76 |
| ▸ | CAMK1D | Q8IU85 | 1/20 | 0.76 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.76 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.69 |
| ▸ | MAPT | P10636 | 7/20 | 0.69 |
| ▸ | LMNA | P02545 | 5/20 | 0.69 |
| ▸ | HPGD | P15428 | 1/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.58 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL913128 | 0.95 | PIKFYVE (0.77) | PIKFYVEFESFERTYK2FRK | |
| SCHEMBL913130 | 0.95 | PIKFYVE (0.77) | PIKFYVEFESFERTYK2FRK | |
| SCHEMBL18165044 | 0.90 | PIKFYVE (0.77) | PIKFYVEFESFERTYK2FRK | |
| SCHEMBL3081115 | 0.89 | PIKFYVE (0.76) | PIKFYVEFESFERTYK2FRK | |
| SCHEMBL3081121 | 0.89 | PIKFYVE (0.76) | PIKFYVEFESFERTYK2FRK | |
| SCHEMBL18115409 | 0.89 | PIKFYVE (0.80) | PIKFYVEFESFERTYK2FRK | |
| SCHEMBL18115257 | 0.88 | PIKFYVE (0.84) | PIKFYVEFESFERTYK2FRK | |
| SCHEMBL912519 | 0.88 | PIKFYVE (0.71) | PIKFYVEFESFERTYK2FRK | |
| SCHEMBL18115311 | 0.88 | PIKFYVE (0.81) | PIKFYVEFESFERTYK2FRK | |
| SCHEMBL18115309 | 0.88 | PIKFYVE (0.81) | PIKFYVEFESFERTYK2FRK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180092923-A1 | METHODS FOR TREATING LYSOSOMAL STORAGE DISORDERS | BIOMARIN PHARMACEUTICAL INC. | 2018-04-05 | — | — | US | disclosed |
| US-20180092923-A1 | METHODS FOR TREATING LYSOSOMAL STORAGE DISORDERS | BIOMARIN PHARMACEUTICAL INC. | 2018-04-05 | — | — | US | disclosed |
| WO-2016168420-A1 | METHODS FOR TREATING LYSOSOMAL STORAGE DISORDERS | BIOMARIN PHARMACEUTICAL INC. (US) | 2016-10-20 | — | — | WO | disclosed |
| US-20100227860-A1 | DISALT INHIBITORS OF IL-12 PRODUCTION | SYNTA PHARMACEUTICALS CORPORATION (US) | 2010-09-09 | — | — | US | disclosed |
| US-20100227860-A1 | DISALT INHIBITORS OF IL-12 PRODUCTION | SYNTA PHARMACEUTICALS CORPORATION (US) | 2010-09-09 | — | — | US | disclosed |
| US-7745436-B2 | Disalt inhibitors of IL-12 production | SYNTA PHARMACEUTICALS CORPORATION (US) | 2010-06-29 | — | — | US | disclosed |
| US-7745436-B2 | Disalt inhibitors of IL-12 production | SYNTA PHARMACEUTICALS CORPORATION (US) | 2010-06-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100227860-A1 | DISALT INHIBITORS OF IL-12 PRODUCTION | IL2, IL6, IL6ST | PIKFYVE 2362/4885FES 1732/4885FER 962/4885 |
| US-20180092923-A1 | METHODS FOR TREATING LYSOSOMAL STORAGE DISORDERS | GAA, GBA1, MAN2B1 | PIKFYVE 1535/4885FES 3310/4885FER 2994/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.