Sugi Predict

Sugi Predict / Targets / IL6

IL6

Interleukin-6 · P05231 · IL6 on Sugi Atlas →

11,767 patent compounds predicted against IL6, 8,583 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL1146480 SCHEMBL1146480 0.75 18/20
SCHEMBL1146053 SCHEMBL1146053 0.77 17/20
SCHEMBL1146678 SCHEMBL1146678 0.64 17/20
SCHEMBL731555 SCHEMBL731555 0.63 17/20
SCHEMBL1146277 SCHEMBL1146277 0.80 16/20
SCHEMBL1344409 SCHEMBL1344409 0.73 16/20
SCHEMBL1146284 SCHEMBL1146284 0.70 16/20
SCHEMBL1146421 SCHEMBL1146421 0.61 16/20
SCHEMBL1146612 SCHEMBL1146612 0.58 16/20
SCHEMBL1146456 SCHEMBL1146456 0.78 15/20
SCHEMBL1146525 SCHEMBL1146525 0.67 15/20
SCHEMBL1146237 SCHEMBL1146237 0.66 15/20
SCHEMBL1146039 SCHEMBL1146039 0.61 15/20
SCHEMBL1146548 SCHEMBL1146548 0.58 15/20
SCHEMBL1146347 SCHEMBL1146347 0.57 15/20
SCHEMBL1146631 SCHEMBL1146631 0.55 15/20
SCHEMBL1146552 SCHEMBL1146552 0.85 14/20
SCHEMBL1145806 SCHEMBL1145806 0.77 14/20
SCHEMBL1146564 SCHEMBL1146564 0.70 14/20
SCHEMBL1146348 SCHEMBL1146348 0.68 14/20

Clinical trials — most relevant to IL6 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Pilot Study of Cefditoren Pivoxil in COVID-19 Patients With Mild to Moderate Pneumonia PHASE4COMPLETED
Extended Steroid in Use in Community Acquired Pneumonia (CAP)(e) PHASE3COMPLETED
The Role of High Dose Co-trimoxazole in Severe Covid-19 Patients PHASE2/PHASE3COMPLETED
Safety and Antiviral Activity of BLD-2660 in COVID-19 Hospitalized Subjects PHASE2COMPLETED
IL-6 Inhibition for Modulating Inflammation After Cardiac Arrest PHASE2COMPLETED
Genistein in trAnSthyretin recePtor Amyloid caRdiomyopathy PHASE1/PHASE2RECRUITING
WJMSCs Anti-inflammatory Therapy in Coronary Artery Disease PHASE2UNKNOWN
PRONTO Trial (PRophylactic Versus ON-demand Use of TOcilizumab) PHASE2RECRUITING
STS Administration on Coronavirus Disease (COVID-19) Patients in Critical Care PHASE2UNKNOWN
A Study to Evaluate TOUR006 in Patients With Chronic Kidney Disease and Elevated Hs-CRP PHASE2COMPLETED
Intraperitoneal Local Anaesthetic in Colonic Surgery PHASE1COMPLETED
An Open-Label Trial of Tocilizumab in Schizophrenia PHASE1COMPLETED
Adding Colchicine to Tocilizumab in Patients With Severe COVID-19 Pneumonia. EARLY_PHASE1UNKNOWN
The Effect of Simvastatin Therapy on the Expression of Procoagulant and Inflammatory Markers in Heart Failure EARLY_PHASE1COMPLETED
Effect of Quranic Recitation and Classical Music on Pain Intensity and Interleukin-6 Levels After Lower Limb Orthopedic Surgery With Intrathecal Anesthesia nanRECRUITING
The Impact of Saline Temperature and Local Anesthetic Adjuvants on Postoperative Shoulder Pain and Inflammatory Marker Levels Following Laparoscopic Cholecystectomy nanENROLLING_BY_INVITATION
Short-Term Application of Tocilizumab Following Myocardial Infarction nanCOMPLETED
Study of CRP, Ferritine and D-Dimer in Covid-19 Patients Admitted To Respiratory ICU in Assuit University Hospitals nanUNKNOWN
Evaluation of Interleukine 6 (and Other Cytokines and Inflammatory Markers) in COVID-19 Patients With a Systemic Inflammatory Response Syndrome nanCOMPLETED
Effect of Pentoxifylline on Prognosis of Coronavirus Disease 2019 (COVID- 19) Infection nanCOMPLETED
Effect of Wet Cupping Versus Moderate Intensity Aerobic Exercise on Inflammatory Markers in Diabetic Patients nanCOMPLETED
Impact of Clinical, Demographic and Laboratory Variables on Brain Natriuretic Peptide Levels nanWITHDRAWN
Investigation of Inflammatory Parameters in a Perioperative Closed-meshed Standard Progress in CPB Patients nanCOMPLETED
Non-surgical Periodontitis Treatment With Aspirin and Omega-3 nanACTIVE_NOT_RECRUITING
Study of the Response and Cardiorespiratory Endurance in Early RA Patients Treated With Tocilizumab or Methotrexate nanCOMPLETED
Can Cytokines Predict the Severity of Acute Mucositis and the Need for Gastrostomy Tubes (PEG)? nanUNKNOWN
Delineating Between Pathophysiologic Phenotypes of Hypoxic Ischemic Brain Injury After Cardiac Arrest nanUNKNOWN
Community-Based Program Integrating Nurse-Led Mind-Body Exercise and Nutrition for Frailty nanNOT_YET_RECRUITING
Hyperoxia vs Normoxia During Cardiopulmonary Bypass nanCOMPLETED
Assessing the Impact of Opioid-Free Anesthesia Using the Modified Mulimix Technique. nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a IL6 binder may also engage these)

ProteinNameSimilarity
Q5I6E3 — 1.000 Q5I6E3 →
P79341 — 1.000 P79341 →
P51494 — 1.000 P51494 →
Q25BC2 — 1.000 Q25BC2 →
P41323 — 1.000 P41323 →
P46650 — 1.000 P46650 →
A3FBE9 — 1.000 A3FBE9 →
Q95181 — 1.000 Q95181 →
B6CKP4 — 0.999 B6CKP4 →
Q865X6 — 0.999 Q865X6 →
Q28747 — 0.998 Q28747 →
Q28319 — 0.998 Q28319 →
P29455 — 0.997 P29455 →
Q8MKH0 — 0.997 Q8MKH0 →
P33093 — 0.997 P33093 →
Q9XT80 — 0.997 Q9XT80 →
Q2PE77 — 0.997 Q2PE77 →
P26893 — 0.996 P26893 →
P0DML2 — 0.996 P0DML2 →
P09056 — 0.996 P09056 →
P41683 — 0.996 P41683 →
Q0GGL7 — 0.996 Q0GGL7 →
P0DML3 — 0.996 P0DML3 →
P58756 — 0.996 P58756 →
Q9IB11 — 0.996 Q9IB11 →
A0S0B0 — 0.996 A0S0B0 →
Q9MZR1 — 0.995 Q9MZR1 →
Q6V919 — 0.995 Q6V919 →
O62754 — 0.995 O62754 →
Q14406 — 0.995 Q14406 →