Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2815919 | 0.91 | TSHR (0.43) | TSHRHTTSMN1; SMN2KDM4ELMNA | |
| SCHEMBL2812071 | 0.88 | SMN1; SMN2 (0.43) | TSHRHTTSMN1; SMN2KDM4ELMNA | |
| SCHEMBL2809514 | 0.88 | HTR6 (0.46) | TSHRKDM4EHPGDHSD17B10ALOX15 | |
| SCHEMBL2811678 | 0.86 | CCNE2 (0.39) | TSHRHTTSMN1; SMN2KDM4ELMNA | |
| SCHEMBL2810425 | 0.85 | SMN1; SMN2 (0.44) | NPC1TSHRHTTSMN1; SMN2KDM4E | |
| SCHEMBL2809527 | 0.84 | MAPT (0.45) | NPC1SMN1; SMN2KDM4EHSD17B10ALDH1A1 | |
| SCHEMBL2810400 | 0.84 | CFTR (0.46) | NPC1TSHRHTTKDM4EHPGD | |
| SCHEMBL2808261 | 0.81 | TSHR (0.45) | TSHRHTTSMN1; SMN2KDM4ELMNA | |
| SCHEMBL2809446 | 0.81 | TSHR (0.38) | TSHRKDM4ELMNAHSD17B10ALDH1A1 | |
| SCHEMBL2814404 | 0.80 | HRH4 (0.44) | TSHRHTTSMN1; SMN2KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010114905-A1 | PERI-FUSED PYRAZOLO-PYRIMIDINE COMPOUNDS | ARQULE, INC. (US) | 2010-10-07 | — | — | WO | disclosed |