Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 3/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.39 |
| ▸ | DRD1 | P21728 | 2/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13145774 | 0.80 | CYP2C19 (0.42) | CYP2D6CYP2C19POLBKCNH2CHRM2 | |
| SCHEMBL13145785 | 0.77 | CYP2D6 (0.32) | CYP2D6KCNA5KCNE1 | |
| SCHEMBL225860 | 0.75 | CYP2D6 (0.52) | CYP2D6CYP2C19KCNH2CHRM2ADRA2A | |
| SCHEMBL6247532 | 0.75 | CYP2D6 (0.47) | CYP2D6CYP2C19POLBKCNH2CHRM2 | |
| SCHEMBL29390583 | 0.75 | CYP2D6 (0.52) | CYP2D6CYP2C19KCNH2CHRM2ADRA2A | |
| SCHEMBL24741515 | 0.75 | CYP2D6 (0.47) | CYP2D6CYP2C19POLBKCNH2CHRM2 | |
| SCHEMBL1921570 | 0.75 | CYP2D6 (0.62) | CYP2D6CYP2C19POLBKCNH2CHRM2 | |
| SCHEMBL2760196 | 0.74 | CYP2D6 (0.55) | CYP2D6CYP2C19POLBKCNH2CHRM2 | |
| Hydrochloric Acid SCHEMBL28665181 | 0.74 | KDM4E (0.53) | CYP2D6CYP2C19KCNH2CHRM2ADRA2A | |
| SCHEMBL2736347 | 0.74 | CYP2C19 (0.50) | CYP2D6CYP2C19POLBKCNH2CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100234364-A1 | CCR2 INHIBITORS AND METHODS OF USE THEREOF | CHEMOCENTRYX, INC. | 2010-09-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100234364-A1 | CCR2 INHIBITORS AND METHODS OF USE THEREOF | CCR2, CCR9, CCR1 | CYP2D6 2049/4885CYP2C19 862/4885POLB 4104/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.