Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 2/20 | 0.60 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | MITF | O75030 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.43 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.43 |
| ▸ | XBP1 | P17861 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8349186 | 0.82 | CHRM2 (0.50) | CHRM2KDM4EGAAMEN1KMT2A | |
| SCHEMBL13675862 | 0.80 | CALM1 (0.50) | KDM4EKMT2AALDH1A1POLB | |
| SCHEMBL22839742 | 0.79 | CHRM2 (0.92) | CHRM2SCN8AKDM4EGAAMEN1 | |
| SCHEMBL2930997 | 0.79 | CHRM2 (0.85) | CHRM2SCN8AKDM4EGAAMEN1 | |
| SCHEMBL2938432 | 0.76 | CHRM2 (0.78) | CHRM2SCN8AKDM4EGAAMEN1 | |
| SCHEMBL10382814 | 0.75 | CHRM2 (0.77) | CHRM2SCN8AKDM4EGAAMEN1 | |
| SCHEMBL5040557 | 0.74 | CHRM2 (0.81) | CHRM2SCN8AKDM4EGAAMEN1 | |
| SCHEMBL4919379 | 0.74 | CHRM2 (0.81) | CHRM2SCN8AKDM4EGAAMEN1 | |
| SCHEMBL4914700 | 0.74 | CHRM2 (0.81) | CHRM2SCN8AKDM4EGAAMEN1 | |
| SCHEMBL536987 | 0.73 | CHRM2 (0.74) | CHRM2SCN8AKDM4EGAAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010114905-A1 | PERI-FUSED PYRAZOLO-PYRIMIDINE COMPOUNDS | ARQULE, INC. (US) | 2010-10-07 | — | — | WO | disclosed |