Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.35 |
| ▸ | MEN1 | O00255 | 6/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.35 |
| ▸ | MAPT | P10636 | 5/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | NPC1 | O15118 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | IDH1 | O75874 | 3/20 | 0.34 |
| ▸ | PPARD | Q03181 | 1/20 | 0.34 |
| ▸ | PPARA | Q07869 | 1/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.33 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.32 |
| ▸ | DCK | P27707 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL577588 | 0.87 | PPARD (0.36) | KMT2AMEN1SMN1; SMN2MAPTKDM4E | |
| SCHEMBL13147670 | 0.85 | KDM4E (0.36) | KMT2AMEN1KDM4EALDH1A1HTT | |
| SCHEMBL14706482 | 0.84 | PPARD (0.33) | KMT2AMEN1SMN1; SMN2MAPTKDM4E | |
| SCHEMBL13147740 | 0.80 | IDH1 (0.41) | KMT2AKDM4EALDH1A1IDH1HSD17B10 | |
| SCHEMBL577242 | 0.80 | PPARD (0.33) | KMT2AMEN1SMN1; SMN2MAPTKDM4E | |
| SCHEMBL13147741 | 0.79 | IDH1 (0.37) | KMT2AMEN1SMN1; SMN2MAPTKDM4E | |
| SCHEMBL13147675 | 0.79 | IDH1 (0.35) | KMT2AMEN1SMN1; SMN2KDM4ENPC1 | |
| SCHEMBL578438 | 0.78 | MAPT (0.38) | KMT2AMEN1SMN1; SMN2MAPTKDM4E | |
| SCHEMBL13147662 | 0.78 | IDH1 (0.36) | KMT2ASMN1; SMN2KDM4ENPC1ALDH1A1 | |
| SCHEMBL13147657 | 0.77 | IDH1 (0.41) | RAB9AIDH1CYP19A1CYP1A2CYP1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010118078-A1 | MACROCYCLIC SERINE PROTEASE INHIBITORS | IDENIX PHARMACEUTICALS, INC. (US) | 2010-10-14 | — | — | WO | disclosed |