Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 2/20 | 0.56 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.55 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.47 |
| ▸ | ESRRG | P62508 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD1 | P21728 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | DRD5 | P21918 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4652352 | 0.84 | CXCR2 (0.57) | CXCR2CXCR1ALDH1A1TSHRHSD11B1 | |
| SCHEMBL16172609 | 0.81 | CXCR2 (0.59) | CXCR2CXCR1ALDH1A1DRD2DRD1 | |
| SCHEMBL13438097 | 0.81 | CXCR2 (0.49) | CXCR2CXCR1ESRRGDRD2DRD1 | |
| Hydrochloric Acid SCHEMBL2424044 | 0.80 | CXCR2 (0.55) | CXCR2CXCR1ESRRGDRD2DRD1 | |
| SCHEMBL1345636 | 0.79 | CXCR2 (0.69) | CXCR2CXCR1TSHR | |
| SCHEMBL245190 | 0.79 | CXCR2 (0.69) | CXCR2CXCR1TSHR | |
| SCHEMBL1820095 | 0.79 | CXCR2 (0.69) | CXCR2CXCR1TSHR | |
| SCHEMBL21226952 | 0.79 | CXCR2 (0.45) | CXCR2CXCR1ESRRGDRD2DRD1 | |
| SCHEMBL2338978 | 0.78 | CXCR2 (0.60) | CXCR2CXCR1ESRRGDRD2DRD1 | |
| SCHEMBL13460874 | 0.78 | CXCR2 (0.60) | CXCR2CXCR1ESRRGDRD2DRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100234591-A1 | BIARYL HETEROCYCLIC COMPOUNDS AND METHODS OF MAKING AND USING THE SAME | RIB-X PHARMACEUTICALS, INC. (US) | 2010-09-16 | — | — | US | disclosed |
| US-7705026-B2 | Biaryl heterocyclic compounds and methods of making and using the same | RIB-X PHARMACEUTICALS, INC. (US) | 2010-04-27 | — | — | US | disclosed |
| US-7456206-B2 | Biaryl heterocyclic compounds and methods of making and using the same | RIB-X PHARMACEUTICALS, INC. (US) | 2008-11-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100234591-A1 | BIARYL HETEROCYCLIC COMPOUNDS AND METHODS OF MAKING AND USING THE SAME | PCNA, AADAC, MIF | CXCR2 354/4885CXCR1 1008/4885ABCB11 580/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.