Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 2/20 | 0.60 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.59 |
| ▸ | CA2 | P00918 | 6/20 | 0.37 |
| ▸ | CA1 | P00915 | 5/20 | 0.37 |
| ▸ | CA9 | Q16790 | 4/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD1 | P21728 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
| ▸ | DRD5 | P21918 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | HTR1D | P28221 | 1/20 | 0.33 |
| ▸ | HTR1B | P28222 | 1/20 | 0.33 |
| ▸ | KIF11 | P52732 | 1/20 | 0.33 |
| ▸ | ESRRG | P62508 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2338978 | 1.00 | CXCR2 (0.60) | CXCR2CXCR1CA2CA1CA9 | |
| SCHEMBL2338983 | 1.00 | CXCR2 (0.60) | CXCR2CXCR1CA2CA1CA9 | |
| Hydrochloric Acid SCHEMBL2339186 | 0.98 | CXCR2 (0.59) | CXCR2CXCR1CA2CA1CA9 | |
| Hydrochloric Acid SCHEMBL2339180 | 0.98 | CXCR2 (0.59) | CXCR2CXCR1CA2CA1CA9 | |
| SCHEMBL4414662 | 0.86 | CXCR2 (0.66) | CXCR2CXCR1CA2CA1CA9 | |
| SCHEMBL252024 | 0.86 | CXCR2 (0.66) | CXCR2CXCR1CA2CA1CA9 | |
| SCHEMBL13433680 | 0.84 | CXCR2 (0.43) | CXCR2CXCR1CA2CA1CA9 | |
| SCHEMBL1345636 | 0.83 | CXCR2 (0.69) | CXCR2CXCR1 | |
| SCHEMBL245190 | 0.83 | CXCR2 (0.69) | CXCR2CXCR1 | |
| SCHEMBL9233582 | 0.83 | CXCR2 (0.43) | CXCR2CXCR1CA2CA1CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7674806-B2 | Amidines and derivatives thereof and pharmaceutical compositions containing them | DOMPÉ FARMACEUTICI S.P.A. (IT) | 2010-03-09 | — | — | US | disclosed |
| US-20070155717-A1 | Amidines and derivatives thereof and pharmaceutical compositions containing them | DOMPE PHA.R.MA S.P.A (IT) | 2007-07-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070155717-A1 | Amidines and derivatives thereof and pharmaceutical compositions containing them | MMP8, CXCL8, MPO | CXCR2 15/4885CXCR1 24/4885CA2 3565/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.