Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | CDK4 | P11802 | 2/20 | 0.47 |
| ▸ | ABL1 | P00519 | 2/20 | 0.45 |
| ▸ | BCR | P11274 | 2/20 | 0.45 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.44 |
| ▸ | EGFR | P00533 | 7/20 | 0.43 |
| ▸ | ERBB3 | P21860 | 6/20 | 0.43 |
| ▸ | TNNI3K | Q59H18 | 2/20 | 0.40 |
| ▸ | BTK | Q06187 | 1/20 | 0.39 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.39 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | TEK | Q02763 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL691633 | 0.90 | EGFR (0.47) | MEN1KMT2ANPC1RAB9ACDK4 | |
| SCHEMBL13148257 | 0.89 | MEN1 (0.52) | MEN1KMT2ANPC1RAB9ACDK4 | |
| SCHEMBL12262384 | 0.86 | EGFR (0.49) | MEN1KMT2ANPC1RAB9ACDK4 | |
| SCHEMBL691344 | 0.78 | MEN1 (0.59) | MEN1KMT2ANPC1RAB9AABL1 | |
| SCHEMBL691637 | 0.75 | EGFR (0.60) | MEN1KMT2ANPC1RAB9ACDK4 | |
| SCHEMBL3487003 | 0.74 | MEN1 (0.61) | MEN1KMT2ANPC1RAB9ACDK4 | |
| SCHEMBL691651 | 0.74 | EGFR (0.56) | MEN1KMT2ANPC1RAB9ACDK4 | |
| SCHEMBL3487000 | 0.73 | MEN1 (0.64) | MEN1KMT2ANPC1RAB9ACDK4 | |
| SCHEMBL30046349 | 0.73 | SCN9A (0.76) | MEN1KMT2ANPC1RAB9ACDK4 | |
| SCHEMBL16158635 | 0.73 | EGFR (0.58) | MEN1KMT2ANPC1RAB9AABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010123870-A1 | HETEROARYL COMPOUNDS AND USES THEREOF | AVILA THERAPEUTICS, INC. (US) | 2010-10-28 | — | — | WO | disclosed |
| WO-2009051822-A1 | HETEROARYL COMPOUNDS AND USES THEREOF | AVILA THERAPEUTICS, INC. (US) | 2009-04-23 | — | — | WO | disclosed |