Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 8/20 | 0.72 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.72 |
| ▸ | PIK3CB | P42338 | 7/20 | 0.72 |
| ▸ | PIK3CG | P48736 | 7/20 | 0.72 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.61 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.55 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.55 |
| ▸ | CLK2 | P49760 | 1/20 | 0.55 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.55 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.55 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.55 |
| ▸ | XIAP | P98170 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CLK1 | P49759 | 1/20 | 0.40 |
| ▸ | TNIK | Q9UKE5 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1885511 | 0.84 | PIK3CD (0.47) | PIK3CDPIK3CAPIK3CBPIK3CGPI4KB | |
| SCHEMBL2326527 | 0.82 | PIK3CD (0.65) | PIK3CDPIK3CAPIK3CBPIK3CGPI4KB | |
| SCHEMBL1786172 | 0.81 | PIK3CD (0.65) | PIK3CDPIK3CAPIK3CBPIK3CGPI4KB | |
| SCHEMBL12991700 | 0.80 | PIK3CG (0.51) | PIK3CDPIK3CAPIK3CBPIK3CGXIAP | |
| SCHEMBL1882046 | 0.79 | PIK3CA (0.43) | PIK3CDPIK3CAPIK3CBPIK3CGPI4KB | |
| SCHEMBL1889405 | 0.76 | PIK3CA (0.50) | PIK3CDPIK3CAPIK3CBPIK3CGPI4KB | |
| SCHEMBL13149722 | 0.75 | PIK3CD (0.49) | PIK3CDPIK3CAPIK3CBPIK3CGPI4KB | |
| SCHEMBL29089052 | 0.74 | PIK3CG (0.39) | PIK3CDPIK3CAPIK3CBPIK3CGXIAP | |
| SCHEMBL24023246 | 0.74 | PIK3CA (0.48) | PIK3CDPIK3CAPIK3CBPIK3CGPI4KB | |
| SCHEMBL13469237 | 0.74 | PIK3CA (0.48) | PIK3CDPIK3CAPIK3CBPIK3CGPI4KB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7799810-B2 | Organic compounds | NOVARTIS AG (CH) | 2010-09-21 | — | — | US | disclosed |
| US-7799810-B2 | Organic compounds | NOVARTIS AG (CH) | 2010-09-21 | — | — | US | disclosed |
| US-20100120865-A1 | Organic compounds | NOVARTIS AG (CH) | 2010-05-13 | — | — | US | disclosed |
| US-20100120865-A1 | Organic compounds | NOVARTIS AG (CH) | 2010-05-13 | — | — | US | disclosed |
| WO-2008000421-A2 | THIAZOLYL UREA DERIVATIVES AS PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | NOVARTIS AG (CH) | 2008-01-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100120865-A1 | Organic compounds | PIK3C3, PIK3R3, PIK3R4 | PIK3CD 10/4885PIK3CA 5/4885PIK3CB 11/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.