Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 17/20 | 0.50 |
| ▸ | PIK3CD | O00329 | 12/20 | 0.50 |
| ▸ | PIK3CG | P48736 | 11/20 | 0.50 |
| ▸ | PIK3CB | P42338 | 10/20 | 0.50 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.42 |
| ▸ | GAK | O14976 | 1/20 | 0.42 |
| ▸ | PRKACG | P22612 | 1/20 | 0.42 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.42 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.40 |
| ▸ | PIK3C2A | O00443 | 1/20 | 0.40 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.40 |
| ▸ | PI4KA | P42356 | 1/20 | 0.40 |
| ▸ | PRKDC | P78527 | 1/20 | 0.40 |
| ▸ | XIAP | P98170 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24023246 | 0.86 | PIK3CA (0.48) | PIK3CAPIK3CDPIK3CGPIK3CBPI4KB | |
| SCHEMBL571452 | 0.86 | PIK3CA (0.69) | PIK3CAPIK3CDPIK3CGPIK3CBPI4KB | |
| SCHEMBL13469237 | 0.86 | PIK3CA (0.48) | PIK3CAPIK3CDPIK3CGPIK3CBPI4KB | |
| SCHEMBL1885511 | 0.86 | PIK3CD (0.47) | PIK3CAPIK3CDPIK3CGPIK3CBPI4KB | |
| SCHEMBL944398 | 0.83 | PIK3CA (0.61) | PIK3CAPIK3CDPIK3CGPIK3CBPI4KB | |
| SCHEMBL15803547 | 0.82 | PIK3CA (0.63) | PIK3CAPIK3CDPIK3CGPIK3CBPI4KB | |
| SCHEMBL30227352 | 0.82 | PIK3CA (0.63) | PIK3CAPIK3CDPIK3CGPIK3CBPI4KB | |
| SCHEMBL1882046 | 0.82 | PIK3CA (0.43) | PIK3CAPIK3CDPIK3CGPIK3CBPI4KB | |
| SCHEMBL24023242 | 0.82 | PIK3CA (0.56) | PIK3CAPIK3CDPIK3CGPIK3CBPI4KB | |
| SCHEMBL1787009 | 0.81 | PIK3CD (0.68) | PIK3CAPIK3CDPIK3CGPIK3CBPI4KB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110105535-A1 | INHIBITORS OF PHOSPHATIDYLINOSITOL 3-KINASE | NOVARTIS AG | 2011-05-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110105535-A1 | INHIBITORS OF PHOSPHATIDYLINOSITOL 3-KINASE | PIK3CA, PIK3CD, PIP4K2C | PIK3CA 1/4885PIK3CD 2/4885PIK3CG 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.