Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | ACACB | O00763 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | MMP9 | P14780 | 1/20 | 0.37 |
| ▸ | MMP14 | P50281 | 1/20 | 0.37 |
| ▸ | PLAU | P00749 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | F10 | P00742 | 1/20 | 0.37 |
| ▸ | PLAT | P00750 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10097368 | 0.96 | RAB9A (0.39) | RAB9ASMN1; SMN2NPC1CYP1A2CYP2D6 | |
| SCHEMBL13152677 | 0.96 | RAB9A (0.39) | RAB9ASMN1; SMN2NPC1CYP1A2CYP2D6 | |
| SCHEMBL13151986 | 0.92 | NPC1 (0.51) | RAB9ASMN1; SMN2NPC1CYP1A2CYP2D6 | |
| SCHEMBL13051587 | 0.92 | RAB9A (0.37) | RAB9ASMN1; SMN2NPC1CYP1A2CYP2D6 | |
| SCHEMBL12489610 | 0.91 | MEN1 (0.38) | RAB9ASMN1; SMN2NPC1CYP1A2CYP2D6 | |
| SCHEMBL10097555 | 0.91 | NPC1 (0.40) | RAB9ASMN1; SMN2NPC1CYP1A2CYP2D6 | |
| SCHEMBL10097435 | 0.91 | MEN1 (0.38) | RAB9ASMN1; SMN2NPC1CYP1A2CYP2D6 | |
| SCHEMBL14467126 | 0.91 | MEN1 (0.39) | RAB9ASMN1; SMN2NPC1CYP1A2CYP2D6 | |
| SCHEMBL14466312 | 0.91 | NPC1 (0.38) | RAB9ASMN1; SMN2NPC1CYP1A2CYP2D6 | |
| SCHEMBL13215084 | 0.90 | NPC1 (0.39) | RAB9ASMN1; SMN2NPC1CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010118009-A1 | HCV INHIBITOR AND THERAPEUTIC AGENT COMBINATIONS | PTC THERAPEUTICS, INC. (US) | 2010-10-14 | — | — | WO | disclosed |
| WO-2007084435-A2 | METHODS FOR TREATING HEPATITIS C | PTC THERAPEUTICS, INC. (US) | 2007-07-26 | — | — | WO | disclosed |