Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 11/20 | 0.77 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.77 |
| ▸ | TSHR | P16473 | 2/20 | 0.77 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.77 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.77 |
| ▸ | PGR | P06401 | 4/20 | 0.74 |
| ▸ | AR | P10275 | 2/20 | 0.74 |
| ▸ | LMNA | P02545 | 2/20 | 0.74 |
| ▸ | SERPINA6 | P08185 | 1/20 | 0.74 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.74 |
| ▸ | F2 | P00734 | 1/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.59 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.58 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.58 |
| ▸ | NR3C1 | P04150 | 3/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9267453 | 1.00 | HIF1A (0.77) | HIF1ACYP3A4TSHRCYP2C9HSD17B10 | |
| SCHEMBL3404879 | 1.00 | HIF1A (0.77) | HIF1ACYP3A4TSHRCYP2C9HSD17B10 | |
| SCHEMBL13103466 | 1.00 | HIF1A (0.77) | HIF1ACYP3A4TSHRCYP2C9HSD17B10 | |
| SCHEMBL6566408 | 1.00 | HIF1A (0.77) | HIF1ACYP3A4TSHRCYP2C9HSD17B10 | |
| SCHEMBL10409155 | 0.92 | HIF1A (0.72) | HIF1ACYP3A4TSHRCYP2C9HSD17B10 | |
| SCHEMBL11042400 | 0.92 | HIF1A (0.72) | HIF1ACYP3A4TSHRCYP2C9HSD17B10 | |
| SCHEMBL11042389 | 0.92 | HIF1A (0.72) | HIF1ACYP3A4TSHRCYP2C9HSD17B10 | |
| SCHEMBL10409156 | 0.92 | HIF1A (0.72) | HIF1ACYP3A4TSHRCYP2C9HSD17B10 | |
| SCHEMBL10409972 | 0.91 | HIF1A (0.71) | HIF1ACYP3A4TSHRCYP2C9HSD17B10 | |
| SCHEMBL10599491 | 0.91 | HIF1A (0.73) | HIF1ACYP3A4TSHRCYP2C9HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010114473-A1 | NOVEL STEROIDAL[3,2-C]PYRAZOL DERIVATIVES WITH GLUCOCORTICOID ACTIVITY | ASTRAZENECA AB (SE) | 2010-10-07 | — | — | WO | disclosed |