Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 11/20 | 0.77 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.77 |
| ▸ | TSHR | P16473 | 2/20 | 0.77 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.77 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.77 |
| ▸ | PGR | P06401 | 4/20 | 0.74 |
| ▸ | AR | P10275 | 2/20 | 0.74 |
| ▸ | LMNA | P02545 | 2/20 | 0.74 |
| ▸ | SERPINA6 | P08185 | 1/20 | 0.74 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.74 |
| ▸ | F2 | P00734 | 1/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.59 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.58 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.58 |
| ▸ | NR3C1 | P04150 | 3/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9267453 | 1.00 | HIF1A (0.77) | HIF1ACYP3A4TSHRCYP2C9HSD17B10 | |
| SCHEMBL13103466 | 1.00 | HIF1A (0.77) | HIF1ACYP3A4TSHRCYP2C9HSD17B10 | |
| SCHEMBL6566408 | 1.00 | HIF1A (0.77) | HIF1ACYP3A4TSHRCYP2C9HSD17B10 | |
| SCHEMBL13152085 | 1.00 | HIF1A (0.77) | HIF1ACYP3A4TSHRCYP2C9HSD17B10 | |
| SCHEMBL10409155 | 0.92 | HIF1A (0.72) | HIF1ACYP3A4TSHRCYP2C9HSD17B10 | |
| SCHEMBL11042400 | 0.92 | HIF1A (0.72) | HIF1ACYP3A4TSHRCYP2C9HSD17B10 | |
| SCHEMBL11042389 | 0.92 | HIF1A (0.72) | HIF1ACYP3A4TSHRCYP2C9HSD17B10 | |
| SCHEMBL10409156 | 0.92 | HIF1A (0.72) | HIF1ACYP3A4TSHRCYP2C9HSD17B10 | |
| SCHEMBL10409972 | 0.91 | HIF1A (0.71) | HIF1ACYP3A4TSHRCYP2C9HSD17B10 | |
| SCHEMBL10599491 | 0.91 | HIF1A (0.73) | HIF1ACYP3A4TSHRCYP2C9HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0436902-B1 | 5-Fluorouracil derivatives | OTSUKA PHARMA CO LTD (JP) | 1995-06-28 | — | — | EP | claimed |
| US-5426198-A | Contacting steroid in solution with chromium ion, hydrogen radical source, reducing agent | THE UPJOHN COMPANY (US) | 1995-06-20 | — | — | US | claimed |
| EP-0374185-B1 | IMPROVED 9$g(a)-DEHALOGENATION PROCESS | THE UPJOHN COMPANY (US) | 1993-02-10 | — | — | EP | claimed |
| EP-0436902-A1 | 5-Fluorouracil derivatives | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1991-07-17 | — | — | EP | claimed |
| US-20100256105-A1 | NOVEL COMPOUNDS | ASTRAZENECA R&D | 2010-10-07 | — | — | US | disclosed |
| US-6828120-B2 | Preparation of 11 beta ,17 alpha ,21- trihydroxy-6 alpha -methylpregna-1,4-diene-3,20-dione 21-acetate; obtain chemical intermediates, incubate reaction mix and enzymes, recover product | PHARMACIA AND UPJOHN COMPANY | 2004-12-07 | — | — | US | disclosed |
| EP-1399463-A1 | PROCESS TO PREPARE 11$g(b),17$g(a),21-TRIHYDROXY-6$g(a)-METHYLPREGNA-1,4-DIENE-3,20-DIONE 21-ACETATE | PHARMACIA & UPJOHN COMPANY (US) | 2004-03-24 | — | — | EP | disclosed |
| US-20030044885-A1 | Process to prepare 11beta, 17alpha,21-trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione 21-acetate | CRIA, INC. | 2003-03-06 | — | — | US | disclosed |
| WO-2002102826-A1 | PROCESS TO PREPARE 11β,17α,21-TRIHYDROXY-6α-METHYLPREGNA-1,4-DIENE-3,20-DIONE 21-ACETATE | PHARMACIA & UPJOHN COMPANY (US) | 2002-12-27 | — | — | WO | disclosed |
| WO-2001004342-A1 | PROCESS TO PREPARE EXEMESTANE | PHARMACIA & UPJOHN COMPANY (US) | 2001-01-18 | — | — | WO | disclosed |
| US-5426198-A | Contacting steroid in solution with chromium ion, hydrogen radical source, reducing agent | THE UPJOHN COMPANY (US) | 1995-06-20 | — | — | US | disclosed |
| EP-0374185-B1 | IMPROVED 9$g(a)-DEHALOGENATION PROCESS | THE UPJOHN COMPANY (US) | 1993-02-10 | — | — | EP | disclosed |
| US-4918065-A | ANTIINFLAMMATORY AGENT | SCHERING AKTIENGESELLSCHAFT (DE) | 1990-04-17 | — | — | US | disclosed |
| US-4912098-A | Antiinflammatory 6 alpha-methylhydrocortisones | SCHERING AKTIENGESELLSCHAFT (DE) | 1990-03-27 | — | — | US | disclosed |
| WO-1989001482-A1 | IMPROVED 9alpha-DEHALOGENATION PROCESS | THE UPJOHN COMPANY (US) | 1989-02-23 | — | — | WO | disclosed |
| EP-0186948-B1 | PROCESS AND INTERMEDIATES FOR THE PREPARATION OF 17ALPHA-HYDROXYPROGESTERONES AND CORTICOIDS FROM AN ENOL STEROID | THE UPJOHN COMPANY (US) | 1989-01-25 | — | — | EP | disclosed |
| US-4613463-A | Process and intermediates for the preparation of 17 alphahydroxyprogesterones and corticoids from an enol steroid | THE UPJOHN COMPANY (US) | 1986-09-23 | — | — | US | disclosed |
| EP-0098568-A2 | Corticoids-containing preparation for topical application | SCHERING AKTIENGESELLSCHAFT (DE) | 1984-01-18 | — | — | EP | disclosed |
| EP-0098566-A2 | Corticoids-containing preparation for topical application | SCHERING AKTIENGESELLSCHAFT (DE) | 1984-01-18 | — | — | EP | disclosed |
| US-4330541-A | ANTIINFLAMMATORY AGENT | SCHERING AKTIENGESELLSCHAFT (DE) | 1982-05-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100256105-A1 | NOVEL COMPOUNDS | F12, C1R, CXCR4 | HIF1A 2414/4885CYP3A4 101/4885TSHR 450/4885 |
| US-20030044885-A1 | Process to prepare 11beta, 17alpha,21-trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione 21-acetate | CYP17A1, CYP51A1, HSD17B11 | HIF1A 584/4885CYP3A4 86/4885TSHR 3016/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.