Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SGK1 | O00141 | 2/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.39 |
| ▸ | BRPF1 | P55201 | 2/20 | 0.39 |
| ▸ | PDE5A | O76074 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | TDO2 | P48775 | 1/20 | 0.38 |
| ▸ | PRMT6 | Q96LA8 | 2/20 | 0.36 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.34 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13152587 | 0.94 | DYRK1A (0.41) | SGK1DYRK1ABRPF1PDE5AIDO1 | |
| SCHEMBL13151945 | 0.93 | GRIK2 (0.40) | SGK1BRPF1IDO1TDO2PRMT6 | |
| SCHEMBL13152186 | 0.92 | KDM4E (0.43) | SGK1DYRK1ABRPF1PDE5AIDO1 | |
| SCHEMBL13152481 | 0.90 | SGK1 (0.41) | SGK1BRPF1PDE5AIDO1TDO2 | |
| SCHEMBL13152254 | 0.89 | SGK1 (0.39) | SGK1BRPF1IDO1TDO2PRMT6 | |
| SCHEMBL13151731 | 0.88 | CNR2 (0.42) | SGK1BRPF1IDO1TDO2PRMT6 | |
| SCHEMBL13152062 | 0.87 | DYRK1A (0.43) | SGK1DYRK1ABRPF1PDE5AKDM4E | |
| SCHEMBL13151897 | 0.87 | DYRK1A (0.43) | DYRK1APDE5AKDM4EALDH1A1MAPK1 | |
| SCHEMBL10097698 | 0.87 | AR (0.41) | SGK1DYRK1APDE5APRMT6 | |
| SCHEMBL10095986 | 0.86 | DYRK1A (0.38) | SGK1DYRK1ABRPF1PDE5AIDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010118009-A1 | HCV INHIBITOR AND THERAPEUTIC AGENT COMBINATIONS | PTC THERAPEUTICS, INC. (US) | 2010-10-14 | — | — | WO | disclosed |