Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SGK1 | O00141 | 2/20 | 0.39 |
| ▸ | BRPF1 | P55201 | 2/20 | 0.36 |
| ▸ | MAP2K4 | P45985 | 2/20 | 0.36 |
| ▸ | PRMT6 | Q96LA8 | 3/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.34 |
| ▸ | KIT | P10721 | 2/20 | 0.33 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.33 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.33 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | TDO2 | P48775 | 1/20 | 0.33 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13152661 | 0.93 | SGK1 (0.40) | SGK1BRPF1MAP2K4PRMT6SCN9A | |
| SCHEMBL13152145 | 0.89 | SGK1 (0.41) | SGK1BRPF1MAP2K4PRMT6ALDH2 | |
| SCHEMBL13151857 | 0.88 | NPC1 (0.37) | KITADORA2AADORA2B | |
| SCHEMBL13151866 | 0.88 | DYRK1A (0.36) | SGK1BRPF1KITADORA2AADORA2B | |
| SCHEMBL10095974 | 0.87 | CYP11B2 (0.35) | SGK1BRPF1MAP2K4PRMT6SCN9A | |
| SCHEMBL13151766 | 0.85 | SGK1 (0.40) | SGK1BRPF1MAP2K4PRMT6SCN9A | |
| SCHEMBL13151842 | 0.84 | TDP1 (0.38) | SGK1MAP2K4 | |
| SCHEMBL13152587 | 0.84 | DYRK1A (0.41) | SGK1BRPF1PRMT6ALDH2IDO1 | |
| SCHEMBL10097698 | 0.84 | AR (0.41) | SGK1PRMT6ADORA2AADORA2B | |
| SCHEMBL13152265 | 0.82 | SGK1 (0.40) | SGK1BRPF1MAP2K4PRMT6SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010118009-A1 | HCV INHIBITOR AND THERAPEUTIC AGENT COMBINATIONS | PTC THERAPEUTICS, INC. (US) | 2010-10-14 | — | — | WO | disclosed |