Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 4/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 3/20 | 0.34 |
| ▸ | CA1 | P00915 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13152598 | 0.91 | CA12 (0.42) | MAPTSMN1; SMN2NPSR1RXFP1DYRK1A | |
| SCHEMBL10249733 | 0.89 | DYRK1A (0.40) | MAPTSMN1; SMN2NPSR1RXFP1DYRK1A | |
| SCHEMBL13152163 | 0.88 | DYRK1A (0.41) | MAPTSMN1; SMN2NPSR1RXFP1DYRK1A | |
| SCHEMBL13152569 | 0.88 | DYRK1A (0.40) | MAPTSMN1; SMN2NPSR1RXFP1DYRK1A | |
| SCHEMBL13152566 | 0.88 | GRIK2 (0.43) | MAPTSMN1; SMN2NPSR1RXFP1DYRK1A | |
| SCHEMBL13152193 | 0.87 | KDM4E (0.39) | MAPTSMN1; SMN2NPSR1RXFP1DYRK1A | |
| SCHEMBL10249314 | 0.87 | DYRK1A (0.41) | MAPTSMN1; SMN2NPSR1RXFP1DYRK1A | |
| SCHEMBL10095365 | 0.85 | MAPT (0.43) | MAPTSMN1; SMN2NPSR1RXFP1DYRK1A | |
| SCHEMBL13152568 | 0.85 | APP (0.45) | MAPTSMN1; SMN2NPSR1RXFP1DYRK1A | |
| SCHEMBL13152171 | 0.83 | DYRK1A (0.40) | MAPTSMN1; SMN2NPSR1RXFP1DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010118009-A1 | HCV INHIBITOR AND THERAPEUTIC AGENT COMBINATIONS | PTC THERAPEUTICS, INC. (US) | 2010-10-14 | — | — | WO | disclosed |