Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 2/20 | 0.36 |
| ▸ | PRKDC | P78527 | 2/20 | 0.36 |
| ▸ | HTR3A | P46098 | 1/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.33 |
| ▸ | MAT2A | P31153 | 1/20 | 0.32 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.31 |
| ▸ | MTOR | P42345 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | PRKACA | P17612 | 1/20 | 0.30 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.30 |
| ▸ | GSK3B | P49841 | 1/20 | 0.30 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.30 |
| ▸ | DRD1 | P21728 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10095958 | 0.86 | CYP11B2 (0.41) | PIK3CAPRKDCHTR3AGRM2MAT2A | |
| SCHEMBL14466152 | 0.86 | PRKACA (0.41) | PIK3CAPRKDCHTR3APRKACARPS6KB1 | |
| SCHEMBL13152261 | 0.84 | HRH3 (0.37) | PIK3CAPRKDCNPC1RAB9AROCK1 | |
| SCHEMBL13152265 | 0.83 | SGK1 (0.40) | PIK3CAPRKDCHTR3AMTOR | |
| SCHEMBL13152313 | 0.83 | PIK3CA (0.36) | PIK3CAPRKDCHTR3AMTORGSK3B | |
| SCHEMBL10097497 | 0.82 | DPP4 (0.37) | PIK3CAPRKDCKMT2AGSK3B | |
| SCHEMBL13152660 | 0.82 | EPHX1 (0.43) | NPC1RAB9AKMT2A | |
| SCHEMBL13152247 | 0.82 | NPC1 (0.39) | PIK3CAPRKDCHTR3ANPC1RAB9A | |
| SCHEMBL13153361 | 0.82 | TDP1 (0.40) | PIK3CAPRKDCMTORKMT2APRKACA | |
| SCHEMBL13152697 | 0.81 | SGK1 (0.40) | PIK3CAPRKDCMTORGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010118009-A1 | HCV INHIBITOR AND THERAPEUTIC AGENT COMBINATIONS | PTC THERAPEUTICS, INC. (US) | 2010-10-14 | — | — | WO | disclosed |