Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 3/20 | 0.43 |
| ▸ | SGK1 | O00141 | 1/20 | 0.41 |
| ▸ | PLK4 | O00444 | 1/20 | 0.41 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.41 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.41 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | ROS1 | P08922 | 1/20 | 0.41 |
| ▸ | PRKACA | P17612 | 1/20 | 0.41 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | MARK3 | P27448 | 1/20 | 0.41 |
| ▸ | TYK2 | P29597 | 1/20 | 0.41 |
| ▸ | AKT1 | P31749 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | CLK2 | P49760 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13152585 | 0.94 | DYRK1A (0.44) | DYRK1ASGK1PLK4DAPK3DYRK3 | |
| SCHEMBL13152695 | 0.94 | DYRK1A (0.42) | DYRK1ASGK1PLK4DCLK1DAPK3 | |
| SCHEMBL13152602 | 0.93 | DYRK1A (0.43) | DYRK1ASGK1PDE5ANPC1CNR2 | |
| SCHEMBL13152362 | 0.91 | GRIK2 (0.43) | DYRK1ASGK1PLK4DCLK1DAPK3 | |
| SCHEMBL13152583 | 0.90 | DYRK1A (0.44) | DYRK1APDE5ANPC1PGRCNR2 | |
| SCHEMBL13152458 | 0.89 | DYRK1A (0.41) | DYRK1ASGK1PLK4DCLK1DAPK3 | |
| SCHEMBL13152062 | 0.88 | DYRK1A (0.43) | DYRK1ASGK1PLK4DAPK3DYRK3 | |
| SCHEMBL13152144 | 0.88 | DYRK1A (0.40) | DYRK1ASGK1PLK4DCLK1DAPK3 | |
| SCHEMBL13152633 | 0.88 | DYRK1A (0.42) | DYRK1APDE5ANPC1PGRCNR2 | |
| SCHEMBL13151948 | 0.86 | GRIK2 (0.42) | DYRK1ASGK1PLK4DCLK1DAPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010118009-A1 | HCV INHIBITOR AND THERAPEUTIC AGENT COMBINATIONS | PTC THERAPEUTICS, INC. (US) | 2010-10-14 | — | — | WO | disclosed |