Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SGK1 | O00141 | 2/20 | 0.39 |
| ▸ | PRMT6 | Q96LA8 | 4/20 | 0.39 |
| ▸ | MAP2K4 | P45985 | 2/20 | 0.36 |
| ▸ | KIT | P10721 | 2/20 | 0.35 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.35 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.35 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | TDO2 | P48775 | 1/20 | 0.35 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.33 |
| ▸ | CTPS1 | P17812 | 1/20 | 0.33 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.32 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10249405 | 0.88 | NPC1 (0.42) | GRIK1GRIK2 | |
| SCHEMBL13152186 | 0.88 | KDM4E (0.43) | SGK1PRMT6MAP2K4BRPF1PRMT1 | |
| SCHEMBL10252757 | 0.88 | PLK4 (0.37) | SGK1KITBRPF1GRIK1GRIK2 | |
| SCHEMBL10095725 | 0.87 | PRMT6 (0.35) | SGK1PRMT6MAP2K4KITPRMT1 | |
| SCHEMBL13152661 | 0.86 | SGK1 (0.40) | SGK1PRMT6MAP2K4KITBRPF1 | |
| SCHEMBL13151739 | 0.86 | IDH1 (0.41) | SGK1PRMT6MAP2K4KITBRPF1 | |
| SCHEMBL13152372 | 0.86 | SGK1 (0.43) | SGK1PRMT6MAP2K4KITBRPF1 | |
| SCHEMBL10097640 | 0.86 | KIT (0.43) | KIT | |
| SCHEMBL10249318 | 0.85 | PLK4 (0.40) | SGK1KITADRB3ADRA1AGRIK1 | |
| SCHEMBL13151765 | 0.85 | BRD4 (0.35) | BRPF1ADRB3ADRA1AGRIK1GRIK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010118009-A1 | HCV INHIBITOR AND THERAPEUTIC AGENT COMBINATIONS | PTC THERAPEUTICS, INC. (US) | 2010-10-14 | — | — | WO | disclosed |