Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 19/20 | 0.45 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.41 |
| ▸ | HRH2 | P25021 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11930853 | 0.84 | AKT1 (0.39) | HRH4HRH3 | |
| SCHEMBL14051055 | 0.80 | HRH4 (0.39) | HRH4PIM1PIM3HRH3KCNH2 | |
| SCHEMBL14050837 | 0.78 | HRH4 (0.34) | HRH4PIM1PIM3HRH3HRH2 | |
| SCHEMBL13153140 | 0.77 | HRH4 (0.53) | HRH4HRH3 | |
| SCHEMBL14545860 | 0.75 | HRH4 (0.34) | HRH4PIM1PIM3HRH3HRH2 | |
| SCHEMBL15393807 | 0.74 | CHEK1 (0.36) | HRH4PIM1PIM3HRH3HRH2 | |
| SCHEMBL11930804 | 0.74 | CHEK1 (0.35) | HRH4PIM1PIM3HRH3HRH2 | |
| SCHEMBL11930800 | 0.73 | CHEK1 (0.36) | HRH4PIM1PIM3HRH3HRH2 | |
| SCHEMBL15393810 | 0.72 | AKT1 (0.39) | HRH4HRH3KCNH2 | |
| SCHEMBL15393817 | 0.72 | AKT1 (0.39) | HRH4HRH3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010124009-A2 | FULLY HUMAN ANTI-VEGF ANTIBODIES AND METHODS OF USING | SCHERING CORPORATION (US) | 2010-10-28 | — | — | WO | disclosed |