⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18023032 | 0.78 | — | — | |
| SCHEMBL11185123 | 0.71 | — | — | |
| SCHEMBL28294612 | 0.70 | — | — | |
| SCHEMBL20610131 | 0.69 | TSHR (0.30) | — | |
| SCHEMBL10826 | 0.69 | TSHR (0.43) | — | |
| Hydrochloric Acid SCHEMBL5560769 | 0.69 | ALDH1A1 (0.32) | — | |
| Hydrochloric Acid SCHEMBL6360099 | 0.69 | — | — | |
| SCHEMBL1263912 | 0.67 | — | — | |
| SCHEMBL4535153 | 0.65 | — | — | |
| SCHEMBL7960223 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9149543-B2 | Methods and models for rapid, widespread delivery of genetic material to the CNS using non-viral, cationic lipid-mediated vectors | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2015-10-06 | — | — | US | disclosed |
| US-9149543-B2 | Methods and models for rapid, widespread delivery of genetic material to the CNS using non-viral, cationic lipid-mediated vectors | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2015-10-06 | — | — | US | disclosed |
| US-20100249208-A1 | Novel Methods and Models for Rapid, Widespread Delivery of Genetic Material to the CNS Using Non-Viral, Cationic Lipid-Mediated Vectors | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2010-09-30 | — | — | US | disclosed |
| US-20100249208-A1 | Novel Methods and Models for Rapid, Widespread Delivery of Genetic Material to the CNS Using Non-Viral, Cationic Lipid-Mediated Vectors | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2010-09-30 | — | — | US | disclosed |
| WO-2007070705-A2 | CATIONIC LIPID-MEDIATED VECTORS | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2007-06-21 | — | — | WO | disclosed |