Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 9/20 | 0.53 |
| ▸ | SRC | P12931 | 1/20 | 0.53 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.53 |
| ▸ | SYK | P43405 | 1/20 | 0.53 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.48 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.48 |
| ▸ | ABL1 | P00519 | 1/20 | 0.48 |
| ▸ | BCR | P11274 | 1/20 | 0.48 |
| ▸ | CDK4 | P11802 | 6/20 | 0.48 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.46 |
| ▸ | PLK1 | P53350 | 7/20 | 0.45 |
| ▸ | CDK1 | P06493 | 3/20 | 0.45 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.45 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.45 |
| ▸ | RET | P07949 | 1/20 | 0.45 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.41 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13154194 | 0.91 | CDK2 (0.52) | CDK2SRCZAP70SYKPIK3CA | |
| SCHEMBL12509738 | 0.91 | CDK2 (0.53) | CDK2SRCZAP70SYKPIK3CA | |
| SCHEMBL12509789 | 0.90 | PIK3CA (0.56) | CDK2SRCZAP70SYKPIK3CA | |
| SCHEMBL12509519 | 0.89 | PIK3CG (0.52) | CDK2SRCZAP70SYKPIK3CA | |
| SCHEMBL12509737 | 0.88 | JAK2 (0.49) | CDK2SRCZAP70SYKPIK3CA | |
| SCHEMBL12509621 | 0.85 | CDK2 (0.49) | CDK2SRCZAP70SYKPIK3CA | |
| SCHEMBL2197545 | 0.83 | CDK2 (0.51) | CDK2SRCZAP70SYKPIK3CA | |
| SCHEMBL12509619 | 0.83 | CACNA1B (0.46) | CDK2SRCZAP70SYKPIK3CA | |
| SCHEMBL14538029 | 0.83 | CDK2 (0.60) | CDK2SRCZAP70SYKPIK3CA | |
| SCHEMBL12509736 | 0.82 | CDK2 (0.55) | CDK2SRCZAP70SYKPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7803806-B2 | Pyrimidinyl-thiophene kinase modulators | SGX PHARMACEUTICALS, INC. (US) | 2010-09-28 | — | — | US | disclosed |
| US-7803806-B2 | Pyrimidinyl-thiophene kinase modulators | SGX PHARMACEUTICALS, INC. (US) | 2010-09-28 | — | — | US | disclosed |
| US-20070117800-A1 | PYRIMIDINYL-THIOPHENE KINASE MODULATORS | SGX PHARMACEUTICALS, INC. (US) | 2007-05-24 | — | — | US | disclosed |
| US-20070117800-A1 | PYRIMIDINYL-THIOPHENE KINASE MODULATORS | SGX PHARMACEUTICALS, INC. (US) | 2007-05-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070117800-A1 | PYRIMIDINYL-THIOPHENE KINASE MODULATORS | MAP3K20, MAP3K6, MAP4K2 | CDK2 110/4885SRC 259/4885ZAP70 360/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.