Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 8/20 | 0.55 |
| ▸ | SRC | P12931 | 5/20 | 0.55 |
| ▸ | ZAP70 | P43403 | 5/20 | 0.55 |
| ▸ | SYK | P43405 | 5/20 | 0.55 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.48 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.48 |
| ▸ | ABL1 | P00519 | 1/20 | 0.48 |
| ▸ | BCR | P11274 | 1/20 | 0.48 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.46 |
| ▸ | CDK1 | P06493 | 2/20 | 0.45 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.45 |
| ▸ | RET | P07949 | 1/20 | 0.45 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.45 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.43 |
| ▸ | KCNH3 | Q9ULD8 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | CDK4 | P11802 | 4/20 | 0.41 |
| ▸ | FLT1 | P17948 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12509738 | 0.85 | CDK2 (0.53) | CDK2SRCZAP70SYKPIK3CA | |
| SCHEMBL13154205 | 0.84 | SOS1 (0.53) | CDK2SRCZAP70SYKPIK3CA | |
| SCHEMBL2197545 | 0.83 | CDK2 (0.51) | CDK2SRCZAP70SYKPIK3CA | |
| SCHEMBL14538029 | 0.83 | CDK2 (0.60) | CDK2SRCZAP70SYKPIK3CA | |
| SCHEMBL12509789 | 0.82 | PIK3CA (0.56) | CDK2SRCZAP70SYKPIK3CA | |
| SCHEMBL13154202 | 0.82 | CDK2 (0.53) | CDK2SRCZAP70SYKPIK3CA | |
| SCHEMBL13154194 | 0.82 | CDK2 (0.52) | CDK2SRCZAP70SYKPIK3CA | |
| SCHEMBL12509621 | 0.82 | CDK2 (0.49) | CDK2SRCZAP70SYKPIK3CA | |
| SCHEMBL12509519 | 0.81 | PIK3CG (0.52) | CDK2SRCZAP70SYKPIK3CA | |
| SCHEMBL7470877 | 0.81 | CDK2 (0.70) | CDK2SRCZAP70SYKPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7977481-B2 | Pyrimidinyl-thiophene kinase modulators | SGX PHARMACEUTICALS, INC. (US) | 2011-07-12 | — | — | US | disclosed |