SCHEMBL13155646

SCHEMBL13155646

COc1ccccc1[SiH2]O

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA1 P00915 4/20 0.55
CA2 P00918 4/20 0.55
CA7 P43166 3/20 0.55
CA9 Q16790 3/20 0.55
CA12 O43570 2/20 0.55
CA14 Q9ULX7 2/20 0.55
CA4 P22748 1/20 0.55
TP53 P04637 2/20 0.50
TSHR P16473 1/20 0.50
ENPP2 Q13822 1/20 0.46
ORAI1 Q96D31 1/20 0.45
ORAI2 Q96SN7 1/20 0.45
ORAI3 Q9BRQ5 1/20 0.45
ALDH1A1 P00352 4/20 0.44
TDP1 Q9NUW8 2/20 0.44
ADRA2B P18089 1/20 0.44
PTGS1 P23219 1/20 0.44
MAPK1 P28482 2/20 0.43
HTT P42858 2/20 0.43
KDM4E B2RXH2 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18692005 0.80 SMN1; SMN2 (0.45) CA1CA2CA7CA9CA12
SCHEMBL28629646 0.80 CA1 (0.60) CA1CA2CA7CA9CA12
SCHEMBL29050166 0.76 CA1 (0.55) CA1CA2CA7CA9CA12
SCHEMBL1263114 0.76 CA1 (0.55) CA1CA2CA7CA9CA12
1,2-Dimethoxybenzene SCHEMBL27891985 0.73 CA1 (0.87) CA1CA2CA7CA9CA12
SCHEMBL2146499 0.73 CA1 (0.50) CA1CA2CA7CA9CA12
1,2-Dimethoxybenzene SCHEMBL105872 0.73 CA1 (1.00) CA1CA2CA7CA9CA12
1,2-Dimethoxybenzene SCHEMBL5308636 0.73 CA1 (1.00) CA1CA2CA7CA9CA12
1,2-Dimethoxybenzene SCHEMBL29351917 0.73 CA1 (1.00) CA1CA2CA7CA9CA12
SCHEMBL8637485 0.73 CA12 (0.35) CA1CA2CA9CA12CA14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114874251-A Silicon center chiral silanol and synthetic method thereof 南方科技大学 2022-08-09 CN disclosed
CN-101105646-B Silanol containing photoconductors XEROX CORP 2011-10-19 CN disclosed
US-7799497-B2 Silanol containing overcoated photoconductors XEROX CORPORATION (US) 2010-09-21 US disclosed
US-7785757-B2 Overcoated photoconductors with thiophosphate containing photogenerating layer XEROX CORPORATION (US) 2010-08-31 US disclosed
US-20080107983-A1 Overcoated photoconductors with thiophosphate containing photogenerating layer XEROX CORPORATION 2008-05-08 US disclosed
US-20080107985-A1 Silanol containing overcoated photoconductors XEROX CORPORATION 2008-05-08 US disclosed
CN-101105646-A Silanol containing photoconductors XEROX CORP (US) 2008-01-16 CN disclosed