Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.60 |
| ▸ | CCR6 | P51684 | 1/20 | 0.55 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.55 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.55 |
| ▸ | FLT3 | P36888 | 4/20 | 0.55 |
| ▸ | MAPT | P10636 | 8/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.53 |
| ▸ | POLB | P06746 | 4/20 | 0.53 |
| ▸ | HPGD | P15428 | 4/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | BLM | P54132 | 1/20 | 0.53 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3397867 | 0.98 | NPC1 (0.58) | NPC1CCR6PDE4BPDE4DFLT3 | |
| SCHEMBL13187811 | 0.88 | ALDH1A1 (0.47) | NPC1MAPTALDH1A1POLBHPGD | |
| SCHEMBL3914715 | 0.85 | FLT3 (0.74) | NPC1CCR6PDE4BPDE4DFLT3 | |
| SCHEMBL3394598 | 0.84 | ALDH1A1 (0.54) | NPC1CCR6PDE4BPDE4DFLT3 | |
| SCHEMBL13159113 | 0.83 | ALDH1A1 (0.60) | NPC1MAPTALDH1A1POLBHPGD | |
| SCHEMBL21045328 | 0.83 | FLT3 (0.67) | NPC1FLT3MAPTALDH1A1POLB | |
| SCHEMBL13183018 | 0.82 | ALDH1A1 (0.57) | NPC1FLT3MAPTALDH1A1POLB | |
| SCHEMBL5453184 | 0.80 | CCR6 (0.60) | NPC1CCR6PDE4BPDE4DFLT3 | |
| SCHEMBL3397527 | 0.80 | FLT3 (0.71) | NPC1CCR6PDE4BPDE4DFLT3 | |
| SCHEMBL3397824 | 0.78 | CCR6 (0.53) | NPC1CCR6PDE4BPDE4DFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100222381-A1 | Cyclopentathiophene/cyclohexathiophene DNA methyltransferase inhibitors | VANKAYALAPATI HARIPRASAD | 2010-09-02 | — | — | US | disclosed |
| US-20100222381-A1 | Cyclopentathiophene/cyclohexathiophene DNA methyltransferase inhibitors | VANKAYALAPATI HARIPRASAD | 2010-09-02 | — | — | US | disclosed |
| WO-2010098866-A1 | CYCLOPENTATHIOPHENE/CYCLOHEXATHIOPHENE DNA METHYLTRANSFERASE INHIBITORS | SUPERGEN, INC. (US) | 2010-09-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100222381-A1 | Cyclopentathiophene/cyclohexathiophene DNA methyltransferase inhibitors | DNMT3B, DNMT1, DNMT3L | NPC1 898/4885CCR6 2654/4885PDE4B 1757/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.