Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MMP12 | P39900 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | RAD52 | P43351 | 1/20 | 0.38 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.38 |
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
| ▸ | PNP | P00491 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | PRNP | P04156 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | QPCT | Q16769 | 2/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3799530 | 0.80 | BRD4 (0.39) | BRD4MEN1KMT2AMMP12ABL1 | |
| SCHEMBL3793421 | 0.80 | BRD4 (0.39) | BRD4MEN1KMT2AMMP12ABL1 | |
| SCHEMBL3802355 | 0.78 | QPCT (0.42) | BRD4MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL7343538 | 0.78 | BRD4 (0.48) | BRD4MEN1KMT2AMMP12ABL1 | |
| SCHEMBL7345911 | 0.78 | BRD4 (0.44) | BRD4MEN1KMT2AMMP12ABL1 | |
| SCHEMBL11097769 | 0.76 | MEN1 (0.59) | BRD4MEN1KMT2AMMP12PNP | |
| SCHEMBL1162204 | 0.74 | MMP12 (0.51) | BRD4MMP12RAD52ALDH1A1MAPT | |
| SCHEMBL25413219 | 0.73 | BRD4 (0.43) | BRD4MEN1KMT2AMMP12ABL1 | |
| SCHEMBL22685864 | 0.73 | BRD4 (0.43) | BRD4MEN1KMT2AMMP12ABL1 | |
| SCHEMBL29745481 | 0.73 | BRD4 (0.43) | BRD4MEN1KMT2AMMP12ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010117425-A1 | CERTAIN SUBSTITUTED PYRIMIDINES, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS FOR THEIR USE | BIOGEN IDEC MA INC. (US) | 2010-10-14 | — | — | WO | disclosed |