Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.46 |
| ▸ | NPC1 | O15118 | 7/20 | 0.46 |
| ▸ | RAB9A | P51151 | 7/20 | 0.46 |
| ▸ | MEN1 | O00255 | 5/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | HPGD | P15428 | 5/20 | 0.46 |
| ▸ | POLB | P06746 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | NR0B1 | P51843 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.41 |
| ▸ | RECQL | P46063 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13166372 | 0.92 | ALDH1A1 (0.44) | ALDH1A1SMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL3356343 | 0.90 | MEN1 (0.59) | ALDH1A1SMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL13336338 | 0.90 | MEN1 (0.59) | ALDH1A1SMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL13166371 | 0.89 | KMT2A (0.45) | ALDH1A1SMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL13166370 | 0.86 | ALDH1A1 (0.47) | ALDH1A1SMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL13184987 | 0.85 | ALDH1A1 (0.42) | ALDH1A1SMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL13166373 | 0.85 | KMT2A (0.43) | ALDH1A1SMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL13166368 | 0.83 | MAPT (0.42) | ALDH1A1SMN1; SMN2MEN1KMT2AMAPT | |
| SCHEMBL13336334 | 0.82 | MEN1 (0.57) | ALDH1A1SMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL3352041 | 0.82 | MEN1 (0.57) | ALDH1A1SMN1; SMN2NPC1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7803945-B2 | Tetrahydropyridothiophenes | 4SC AG (DE) | 2010-09-28 | — | — | US | disclosed |
| US-20090270378-A1 | NOVEL TETRAHYDROPYRIDOTHIOPHENES | NYCOMED GMBH (DE) | 2009-10-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090270378-A1 | NOVEL TETRAHYDROPYRIDOTHIOPHENES | BAX, BCL2, CCAR2 | ALDH1A1 686/4885SMN1; SMN2 3183/4885NPC1 4710/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.