Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 20/20 | 0.68 |
| ▸ | KDR | P35968 | 19/20 | 0.68 |
| ▸ | AURKA | O14965 | 1/20 | 0.56 |
| ▸ | FPR1 | P21462 | 1/20 | 0.56 |
| ▸ | FPR3 | P25089 | 1/20 | 0.56 |
| ▸ | GPR183 | P32249 | 1/20 | 0.56 |
| ▸ | SMO | Q99835 | 1/20 | 0.56 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13167393 | 0.90 | MET (0.66) | METKDR | |
| SCHEMBL18516657 | 0.85 | MET (0.71) | METKDR | |
| SCHEMBL18516660 | 0.85 | MET (0.67) | METKDR | |
| SCHEMBL3621799 | 0.85 | MET (0.81) | METKDRAURKAFPR1FPR3 | |
| SCHEMBL307504 | 0.84 | MET (0.63) | METKDR | |
| SCHEMBL10255093 | 0.84 | MET (0.83) | METKDR | |
| SCHEMBL306466 | 0.83 | MET (0.81) | METKDR | |
| SCHEMBL12229331 | 0.83 | MET (0.62) | METKDR | |
| SCHEMBL10255099 | 0.82 | MET (0.81) | METKDR | |
| SCHEMBL3625067 | 0.82 | MET (0.68) | METKDRAURKAFPR1FPR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7790729-B2 | Inhibitors of VEGF receptor and HGF receptor signaling | METHYLGENE INC. (CA) | 2010-09-07 | — | — | US | disclosed |