Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 8/20 | 0.64 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.64 |
| ▸ | RORC | P51449 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13168150 | 0.95 | KCNH2 (0.61) | KCNH2HRH3RORC | |
| SCHEMBL12863267 | 0.84 | HRH3 (0.69) | KCNH2HRH3 | |
| SCHEMBL1128120 | 0.78 | KCNH2 (1.00) | KCNH2HRH3 | |
| SCHEMBL1128396 | 0.78 | KCNH2 (1.00) | KCNH2HRH3 | |
| Hydrochloric Acid SCHEMBL1141460 | 0.78 | KCNH2 (0.98) | KCNH2HRH3 | |
| Hydrochloric Acid SCHEMBL1141464 | 0.78 | KCNH2 (0.98) | KCNH2HRH3 | |
| SCHEMBL12855839 | 0.77 | KCNH2 (0.59) | KCNH2HRH3 | |
| SCHEMBL3634618 | 0.77 | KCNH2 (0.60) | KCNH2HRH3 | |
| SCHEMBL3636340 | 0.76 | KCNH2 (0.57) | KCNH2HRH3 | |
| SCHEMBL1128041 | 0.76 | KCNH2 (0.58) | KCNH2HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100240653-A1 | BIPHENYL SULFONYL AND PHENYL-HETEROARYL SULFONYL MODULATORS OF THE HISTAMINE H3-RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. | 2010-09-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100240653-A1 | BIPHENYL SULFONYL AND PHENYL-HETEROARYL SULFONYL MODULATORS OF THE HISTAMINE H3-RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | HRH3, HRH4, HRH1 | KCNH2 1344/4885HRH3 1/4885RORC 132/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.