Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 10/20 | 0.51 |
| ▸ | MAPT | P10636 | 9/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.51 |
| ▸ | RAB9A | P51151 | 8/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.50 |
| ▸ | BCHE | P06276 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.45 |
| ▸ | RELA | Q04206 | 1/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13191838 | 0.86 | NPC1 (0.51) | NPC1MAPTKDM4ERAB9ASMN1; SMN2 | |
| SCHEMBL13170756 | 0.77 | NPC1 (0.60) | NPC1MAPTKDM4ERAB9ASMN1; SMN2 | |
| SCHEMBL710433 | 0.76 | NPC1 (0.71) | NPC1MAPTKDM4ERAB9ASMN1; SMN2 | |
| SCHEMBL4954320 | 0.75 | NPC1 (0.81) | NPC1MAPTKDM4ERAB9ASMN1; SMN2 | |
| SCHEMBL13170662 | 0.74 | DHODH (0.57) | NPC1MAPTKDM4ERAB9ASMN1; SMN2 | |
| SCHEMBL9453978 | 0.74 | NPC1 (0.68) | NPC1MAPTKDM4ERAB9ASMN1; SMN2 | |
| SCHEMBL13191834 | 0.74 | DHODH (0.60) | NPC1MAPTKDM4ERAB9ASMN1; SMN2 | |
| SCHEMBL13170666 | 0.71 | NPC1 (0.56) | NPC1MAPTKDM4ERAB9ASMN1; SMN2 | |
| SCHEMBL24596471 | 0.70 | NPC1 (0.72) | NPC1MAPTKDM4ERAB9ASMN1; SMN2 | |
| SCHEMBL708285 | 0.70 | NPC1 (0.72) | NPC1MAPTKDM4ERAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180043039-A1 | Lipid-Based Nanoparticles | BOARD OF REGENTS OF THE UNIV OF HOUSTON SYSTEM (US) | 2018-02-15 | — | — | US | disclosed |
| US-9801957-B2 | Lipid-based nanoparticles | Alzeca Biosciences, LLC | 2017-10-31 | — | — | US | disclosed |
| US-20120258044-A1 | LIPID-BASED NANOPARTICLES | Alzeca Biosciences, LLC | 2012-10-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120258044-A1 | LIPID-BASED NANOPARTICLES | APP, PSEN1, PSEN2 | NPC1 30/4885MAPT 9/4885KDM4E 4454/4885 |
| US-20180043039-A1 | Lipid-Based Nanoparticles | APP, PSEN1, PSEN2 | NPC1 30/4885MAPT 9/4885KDM4E 4454/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.