Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 17/20 | 0.47 |
| ▸ | WDR77 | Q9BQA1 | 17/20 | 0.47 |
| ▸ | PI4KA | P42356 | 1/20 | 0.46 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.46 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.46 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18026198 | 1.00 | PRMT5 (0.47) | PRMT5WDR77PI4KAPI4K2BPI4K2A | |
| SCHEMBL18009834 | 0.90 | PI4KA (0.58) | PRMT5WDR77PI4KAPI4K2BPI4K2A | |
| SCHEMBL18009818 | 0.90 | PI4KA (0.58) | PRMT5WDR77PI4KAPI4K2BPI4K2A | |
| SCHEMBL18026201 | 0.88 | PI4KA (0.45) | PRMT5WDR77PI4KAPI4K2BPI4K2A | |
| SCHEMBL18009709 | 0.87 | PRMT5 (0.43) | PRMT5WDR77PI4KAPI4K2BPI4K2A | |
| SCHEMBL18026299 | 0.85 | PI4KA (0.38) | PRMT5WDR77PI4KAPI4K2BPI4K2A | |
| SCHEMBL18026297 | 0.85 | PI4KA (0.43) | PRMT5WDR77PI4KAPI4K2BPI4K2A | |
| SCHEMBL26558035 | 0.85 | PRMT5 (0.47) | PRMT5WDR77 | |
| SCHEMBL18026301 | 0.84 | PRMT5 (0.45) | PRMT5WDR77PI4KAPI4K2BPI4K2A | |
| SCHEMBL18009671 | 0.84 | PRMT5 (0.45) | PRMT5WDR77PI4KAPI4K2BPI4K2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170136024-A1 | INHIBITORS OF E1 ACTIVATING ENZYMES | MILLENNIUM PHARMACEUTICALS, INC. | 2017-05-18 | — | — | US | disclosed |
| US-20130289037-A1 | INHIBITORS OF E1 ACTIVTING ENZYMES | MILLENNIUM PHARM INC (US) | 2013-10-31 | — | — | US | disclosed |
| US-20130165457-A9 | INHIBITORS OF E1 ACTIVATING ENZYMES | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2013-06-27 | — | — | US | disclosed |
| US-20120258927-A1 | INHIBITORS OF E1 ACTIVATING ENZYMES | MILLENIUM PHARMACEUTICALS, INC. (US) | 2012-10-11 | — | — | US | disclosed |
| US-20120258977-A1 | INHIBITORS OF E1 ACTIVATING ENZYMES | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2012-10-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120258977-A1 | INHIBITORS OF E1 ACTIVATING ENZYMES | ECE1, RNASE1, RCE1 | PRMT5 870/4885WDR77 2632/4885PI4KA 1991/4885 |
| US-20120258927-A1 | INHIBITORS OF E1 ACTIVATING ENZYMES | ECE1, RNASE1, RCE1 | PRMT5 870/4885WDR77 2632/4885PI4KA 1991/4885 |
| US-20170136024-A1 | INHIBITORS OF E1 ACTIVATING ENZYMES | ECE1, RNASE1, RCE1 | PRMT5 870/4885WDR77 2632/4885PI4KA 1991/4885 |
| US-20130165457-A9 | INHIBITORS OF E1 ACTIVATING ENZYMES | ECE1, RNASE1, RCE1 | PRMT5 870/4885WDR77 2632/4885PI4KA 1991/4885 |
| US-20130289037-A1 | INHIBITORS OF E1 ACTIVTING ENZYMES | RNASE1, ECE1, CES1 | PRMT5 822/4885WDR77 2267/4885PI4KA 2210/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.