RNASE1 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL2056750	1.00	1/20
SCHEMBL3279568	1.00	1/20
SCHEMBL7875887	1.00	1/20
SCHEMBL7875892	1.00	1/20
SCHEMBL265600	0.74	1/20
SCHEMBL265601	0.74	1/20
SCHEMBL6075436	0.74	1/20
SCHEMBL7996664	0.73	1/20
SCHEMBL1334032	0.71	1/20
SCHEMBL1334035	0.71	1/20
SCHEMBL3337696	0.71	1/20
SCHEMBL3230615	0.70	1/20
SCHEMBL3230623	0.70	1/20
SCHEMBL6320524	0.70	1/20
SCHEMBL523267	0.69	1/20
SCHEMBL523268	0.69	1/20
SCHEMBL2056647	0.69	1/20
SCHEMBL4286458	0.69	1/20
SCHEMBL767324	0.68	1/20
SCHEMBL774263	0.68	1/20

Clinical trials — most relevant to RNASE1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Pancreatic Enzyme Replacement in Acute Necrotizing Pancreatitis	PHASE3	RECRUITING
Pancreatic Enzyme Supplementation in Patients With Unresectable Pancreatic Cancer (PESUP)	PHASE2	COMPLETED
Hydroxychloroquine and Metabolic Outcomes in Patients Undergoing TPAIT	PHASE2	COMPLETED
Clinical Study of EBV-LMP1 Targeted DNAzyme to Treat Nasopharyngeal Carcinoma	PHASE1/PHASE2	COMPLETED
EndoTAG-1 / Gemcitabine Combination Therapy to Treat Locally Advanced and/or Metastatic Adenocarcinoma of the Pancreas	PHASE2	COMPLETED
HRS-4642 in Combination With AG for Neoadjuvant and Adjuvant Treatment of Pancreatic Cancer	PHASE2	RECRUITING
Study of Safety and Efficacy of LEE011 and Ceritinib in Patients With ALK-positive Non-small Cell Lung Cancer.	PHASE1	COMPLETED
Afatinib and Gemcitabine/Nab-paclitaxel in Metastatic Pancreatic Cancer	PHASE1	UNKNOWN
Bortezomib, Fluorouracil, and External-Beam Radiation Therapy in Treating Patients With Stage II, Stage III, or Stage IV Rectal Cancer	PHASE1	COMPLETED
Acute Pancreatitis Targets (APT) Study	nan	COMPLETED
Markers in Acute Pancreatitis-1	nan	COMPLETED
Small Intestinal Bacterial Overgrowth (SIBO) in Pancreatic Adenocarcinoma (PDAC)	nan	RECRUITING
PROOF: Pancreatitis-associated Risk Of Organ Failure	nan	COMPLETED
Convertases and Pancreatic Cancer: Cohort of Patients Treated for Pancreatic Adenocarcinoma	nan	RECRUITING
CIRcular and Non-coding RNAs as Clinically USeful Biomarkers in Pancreaticobiliary Cancers	nan	UNKNOWN
Study of Peripheral Blood Non-coding RNAs as Diagnosis and Prognosis Biomarker for Acute Pancreatitis	nan	COMPLETED
MicroRNAs as Bile-based Biomarkers in Pancreaticobiliary Cancers	nan	COMPLETED
Detection of MicroRNA-25 in the Diagnosis of Pancreatic Cancer	nan	UNKNOWN
Correlation of Polymorphisms of Lipoprotein Lipase (LpL) and Apolipoprotein E (Apo E) With Lipid Profile of Children With Acute Lymphoblastic Eukaemia During Therapy With L - Asparaginase.	nan	UNKNOWN
Detection of Cancer-Specific Active Proteases in Blood Via Fluorescence	nan	WITHDRAWN
A Cohort Study on Screening and Follow-up of High-risk Population of PDAC Based on EUS	nan	NOT_YET_RECRUITING
MiRNA as a Diagnostic and Prognostic Biomarker of Hepatocellular Carcinoma	nan	UNKNOWN
Predicting Pancreatic Necrosis Using mitDNA	nan	UNKNOWN
The Occurence of Pancreatic Cancer Studied in Association With Newly Diagnosed Diabetes in the Elderly	nan	UNKNOWN
Interrogation of Exosome-mediated Intercellular Signaling in Patients With Pancreatic Cancer	nan	RECRUITING
Circulating Extracellular Exosomal Small RNA as Potential Biomarker for Human Pancreatic Cancer	nan	UNKNOWN
The Association Between Post-ERCP Acute Pancreatitis and Various Genetic Mutations	nan	COMPLETED
Studying Fibroblast Activity in Patients With Localized Pancreatic Cancer Undergoing Surgery	nan	COMPLETED
Pancreatic Cancer Screening Using the Enzeavour Assay in Japan	nan	RECRUITING
Perioperative Cancer Cell Dissemination and Systemic Immune Suppression in Resectable Ductal Pancreatic Adenocarcinoma	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a RNASE1 binder may also engage these)

Protein	Name	Similarity
Q8SQ07	—	1.000	Q8SQ07 →
Q8SQ08	—	1.000	Q8SQ08 →
Q8SQ06	—	1.000	Q8SQ06 →
Q8SQ13	—	1.000	Q8SQ13 →
Q8SQ14	—	1.000	Q8SQ14 →
P61822	—	1.000	P61822 →
Q8SPN5	—	1.000	Q8SPN5 →
Q8SQ09	—	1.000	Q8SQ09 →
Q8SQ11	—	1.000	Q8SQ11 →
Q8SQ12	—	1.000	Q8SQ12 →
Q8SPN3	—	1.000	Q8SPN3 →
Q9WUV5	—	0.999	Q9WUV5 →
Q9WUX4	—	0.999	Q9WUX4 →
Q8SQ05	—	0.999	Q8SQ05 →
Q8VD93	—	0.998	Q8VD93 →
P00683	—	0.998	P00683 →
Q8SQ04	—	0.998	Q8SQ04 →
Q8SPN4	—	0.997	Q8SPN4 →
P39873	—	0.997	P39873 →
Q9WUS3	—	0.997	Q9WUS3 →
P61821	—	0.997	P61821 →
P00684	—	0.997	P00684 →
O46532	—	0.997	O46532 →
Q8SPZ5	—	0.996	Q8SPZ5 →
Q9WUR3	—	0.995	Q9WUR3 →
Q9QYX3	—	0.995	Q9QYX3 →
Q9WUS2	—	0.995	Q9WUS2 →
P31347	—	0.995	P31347 →
Q8SPZ7	—	0.994	Q8SPZ7 →
Q9WUX3	—	0.994	Q9WUX3 →