Betulin

Betulin

SCHEMBL131739

C=C(C)[C@@H]1CC[C@]2(CO)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTPN1 P18031 4/20 1.00
TOP2A P11388 2/20 1.00
USP2 O75604 2/20 1.00
LMNA P02545 2/20 1.00
HIF1A Q16665 2/20 1.00
NT5E P21589 2/20 1.00
RELA Q04206 1/20 1.00
CES2 O00748 2/20 0.74
CES1 P23141 2/20 0.74
RORC P51449 4/20 0.70
ALB P02768 3/20 0.70
AKR1B10 O60218 1/20 0.70
POLB P06746 1/20 0.70
GLI1 P08151 1/20 0.70
AKR1B1 P15121 1/20 0.70
DPP4 P27487 1/20 0.70
GPBAR1 Q8TDU6 1/20 0.70
SAE1 Q9UBE0 1/20 0.70
UBA2 Q9UBT2 1/20 0.70
SLC10A1 Q14973 2/20 0.70

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Betulin SCHEMBL14397735 1.00 PTPN1 (1.00) PTPN1TOP2AUSP2LMNAHIF1A
Betulin SCHEMBL8223535 1.00 PTPN1 (1.00) PTPN1TOP2AUSP2LMNAHIF1A
Betulin SCHEMBL17749655 1.00 PTPN1 (1.00) PTPN1TOP2AUSP2LMNAHIF1A
Betulin SCHEMBL19452465 1.00 PTPN1 (1.00) PTPN1TOP2AUSP2LMNAHIF1A
Betulin SCHEMBL13098066 1.00 PTPN1 (1.00) PTPN1TOP2AUSP2LMNAHIF1A
Betulin SCHEMBL14144235 1.00 PTPN1 (1.00) PTPN1TOP2AUSP2LMNAHIF1A
Betulin SCHEMBL14339169 1.00 PTPN1 (1.00) PTPN1TOP2AUSP2LMNAHIF1A
Betulin SCHEMBL14368529 1.00 PTPN1 (1.00) PTPN1TOP2AUSP2LMNAHIF1A
Betulin SCHEMBL13469520 1.00 PTPN1 (1.00) PTPN1TOP2AUSP2LMNAHIF1A
Betulin SCHEMBL20776118 1.00 PTPN1 (1.00) PTPN1TOP2AUSP2LMNAHIF1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 7800 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4748895-A1 BONDING A FOAM, SENSOR OR FUNCTIONAL PART INSIDE A TIRE WITH A PRESSURE SENSITIVE HOTMELT ADHESIVE Henkel AG & Co. KGaA (DE) 2026-05-27 EP claimed
US-12636314-B1 Zinc oxide formulation and associated applicator and packaging system SAGE PRODUCTS, LLC (US) 2026-05-26 US claimed
US-20260137612-A1 COMPOSITION FOR RELIEVING SKIN ITCHING OR SKIN SOOTHING LG H&H CO., LTD. (KR) 2026-05-21 US claimed
CN-119462813-B Dendritic organic monomer of betulinol, composite resin and preparation method 东华大学 2026-05-19 CN claimed
CN-122056926-A Probiotic composition containing melatonin and application of composition in sleep 南京北极光生物科技有限公司 2026-05-19 CN claimed
CN-122056788-A Composition for improving skin itch or calming skin 株式会社LG生活健康 2026-05-19 CN claimed
CN-122031397-A Method for improving solubility and stability of betulinol 甘肃农业大学 2026-05-15 CN claimed
WO-2026100859-A1 COSMETIC COMPOSITION FOR IMPROVING PHOTOAGING AND THERMAL AGING, AND MANUFACTURING METHOD THEREFOR 서린컴퍼니(주) 2026-05-15 WO claimed
CN-122028909-A Lipid nanoparticles with non-covalent bifunctional conjugates for active targeting 莫特治疗股份有限公司 2026-05-12 CN claimed
CN-122005562-A Application of arecoline derivative in killing Bendengzhen in marine culture fish 西北农林科技大学 2026-05-12 CN claimed
WO-2000024762-A1 BETULINIC ACID AND DERIVATIVES THEREOF USEFUL FOR THE TREATMENT OF NEUROECTODERMAL TUMORS Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts (DE) 2000-05-04 WO claimed
EP-0988311-A1 BETULINOL DERIVATIVES CORNELL RESEARCH FOUNDATION, INC. (US) 2000-03-29 EP claimed
US-6022558-A USING CHINESE HERB MEDICINE ENHANCER AS A TRANSDERMAL ABSORPTION ENHANCER; PREPARATION INCLUDES ACTIVE INGREDIENT POSSESSING ANTI-INFLAMMATORY AND ANALGESIC PROPERTIES AND 0.1% TO 70% OF PURE CHINESE HERB ENHANCER NATIONAL RESEARCH INSTITUTE OF CHINESE MEDICINE (TW) 2000-02-08 US claimed
WO-1999016449-A1 SPECIFIC STEADY-STATE R-TYPE Ca2+ CHANNEL BLOCKERS AND USE THEREOF UNIVERSITE DE SHERBROOKE (CA) 1999-04-08 WO claimed
WO-1998055497-A1 BETULINOL DERIVATIVES CORNELL RESEARCH FOUNDATION, INC. (US) 1998-12-10 WO claimed
WO-1998043936-A2 IMPROVED METHODS OF MANUFACTURING BETULINIC ACID THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) 1998-10-08 WO claimed
US-5804575-A Methods of manufacturing betulinic acid THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) 1998-09-08 US claimed
EP-0858805-A2 Transdermal preparations of oxicams National Research Institute of Chinese Medicine (TW) 1998-08-19 EP claimed
US-4422974-A CRYSTALLIZATION FROM ORGANIC SOLVENT-WATER MIXTURE OY KAUKAS AB (FI) 1983-12-27 US claimed
US-4044031-A Process for the separation of sterols JOHANSSON AKE ALLAN 1977-08-23 US claimed