Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.78 |
| ▸ | POLB | P06746 | 3/20 | 0.73 |
| ▸ | TP53 | P04637 | 6/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.69 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.69 |
| ▸ | HPGD | P15428 | 1/20 | 0.69 |
| ▸ | MEN1 | O00255 | 4/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.68 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.68 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.68 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.68 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.68 |
| ▸ | SCD | O00767 | 1/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.60 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.58 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12963192 | 0.91 | TP53 (0.69) | MAPTPOLBTP53ALDH1A1NPSR1 | |
| SCHEMBL24711450 | 0.90 | MAPT (0.69) | MAPTPOLBTP53ALDH1A1NPSR1 | |
| SCHEMBL16774973 | 0.86 | MAPT (0.77) | MAPTTP53ALDH1A1KDM4EHPGD | |
| SCHEMBL12963202 | 0.85 | TP53 (0.71) | MAPTPOLBTP53ALDH1A1NPSR1 | |
| SCHEMBL12963468 | 0.85 | MAPT (0.76) | MAPTPOLBTP53ALDH1A1NPSR1 | |
| SCHEMBL12963175 | 0.85 | MAPT (0.75) | MAPTPOLBTP53ALDH1A1NPSR1 | |
| SCHEMBL12963241 | 0.84 | MAPT (0.67) | MAPTPOLBTP53ALDH1A1NPSR1 | |
| SCHEMBL24710841 | 0.84 | MAPT (0.72) | MAPTPOLBTP53ALDH1A1NPSR1 | |
| SCHEMBL16602324 | 0.84 | TP53 (0.75) | MAPTPOLBTP53ALDH1A1NPSR1 | |
| SCHEMBL12963196 | 0.83 | MAPT (0.78) | MAPTPOLBTP53ALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8993604-B2 | Treatment and prevention of dengue virus infections | SIGA TECHNOLOGIES, INC. (US) | 2015-03-31 | — | — | US | disclosed |
| US-8993604-B2 | Treatment and prevention of dengue virus infections | SIGA TECHNOLOGIES, INC. (US) | 2015-03-31 | — | — | US | disclosed |
| US-20120258079-A1 | Treatment and Prevention of Dengue Virus Infections | SIGA TECHNOLOGIES, INC. | 2012-10-11 | — | — | US | disclosed |
| US-20120258079-A1 | Treatment and Prevention of Dengue Virus Infections | SIGA TECHNOLOGIES, INC. | 2012-10-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120258079-A1 | Treatment and Prevention of Dengue Virus Infections | HAVCR2, TTPA, CHIA | MAPT 118/4885POLB 4481/4885TP53 2739/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.